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10.1073/pnas.2026153118

http://scihub22266oqcxt.onion/10.1073/pnas.2026153118
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33688034!8000430!33688034
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suck abstract from ncbi


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pmid33688034      Proc+Natl+Acad+Sci+U+S+A 2021 ; 118 (12): ä
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  • A safe and highly efficacious measles virus-based vaccine expressing SARS-CoV-2 stabilized prefusion spike #MMPMID33688034
  • Lu M; Dravid P; Zhang Y; Trivedi S; Li A; Harder O; Kc M; Chaiwatpongsakorn S; Zani A; Kenney A; Zeng C; Cai C; Ye C; Liang X; Shimamura M; Liu SL; Mejias A; Ramilo O; Boyaka PN; Qiu J; Martinez-Sobrido L; Yount JS; Peeples ME; Kapoor A; Niewiesk S; Li J
  • Proc Natl Acad Sci U S A 2021[Mar]; 118 (12): ä PMID33688034show ga
  • The current pandemic of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlights an urgent need to develop a safe, efficacious, and durable vaccine. Using a measles virus (rMeV) vaccine strain as the backbone, we developed a series of recombinant attenuated vaccine candidates expressing various forms of the SARS-CoV-2 spike (S) protein and its receptor binding domain (RBD) and evaluated their efficacy in cotton rat, IFNAR(-/-)mice, IFNAR(-/-)-hCD46 mice, and golden Syrian hamsters. We found that rMeV expressing stabilized prefusion S protein (rMeV-preS) was more potent in inducing SARS-CoV-2-specific neutralizing antibodies than rMeV expressing full-length S protein (rMeV-S), while the rMeVs expressing different lengths of RBD (rMeV-RBD) were the least potent. Animals immunized with rMeV-preS produced higher levels of neutralizing antibody than found in convalescent sera from COVID-19 patients and a strong Th1-biased T cell response. The rMeV-preS also provided complete protection of hamsters from challenge with SARS-CoV-2, preventing replication in lungs and nasal turbinates, body weight loss, cytokine storm, and lung pathology. These data demonstrate that rMeV-preS is a safe and highly efficacious vaccine candidate, supporting its further development as a SARS-CoV-2 vaccine.
  • |*Genetic Vectors/genetics/immunology[MESH]
  • |*Measles virus/genetics/immunology[MESH]
  • |Animals[MESH]
  • |Antibodies, Neutralizing/immunology[MESH]
  • |Antibodies, Viral/immunology[MESH]
  • |COVID-19 Vaccines/genetics/*immunology[MESH]
  • |COVID-19/complications/pathology/*prevention & control[MESH]
  • |Cricetinae[MESH]
  • |Disease Models, Animal[MESH]
  • |Gene Expression[MESH]
  • |Humans[MESH]
  • |Immunization[MESH]
  • |Immunogenicity, Vaccine[MESH]
  • |Mice[MESH]
  • |Mice, Transgenic[MESH]
  • |Rats[MESH]
  • |Spike Glycoprotein, Coronavirus/genetics/*immunology[MESH]


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