Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1111/febs.15807 http://scihub22266oqcxt.onion/10.1111/febs.15807 33686748!9545938!33686748     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       FEBS+J 2022 ; 289 (4): 955-964 Nephropedia Template TP {{tp|p=33686748|t=2022. Nicotinamide pathways as the root cause of sepsis - an evolutionary perspective on macrophage energetic shifts |pdf=|usr=}}{{33686748}} gab.com Text Nicotinamide pathways as the root cause of sepsis - an evolutionary perspective on macrophage energetic shifts JO: FEBS J http://www.kidney.de/pget.php?&tw=1&pmid=33686748 #FOAvip Divergent pathways of macrophage metabolism occur during infection, notably switching between oxidative phosphorylation and aerobic glycolysis (Warburg-like metabolism). Concurrently, macrophages shift between alternate and classical activation. A key enzyme upregulated in alternatively activated macrophages is indoleamine 2,3-dioxygenase, which converts tryptophan to kynurenine for de novo synthesis of nicotinamide. Nicotinamide can be used to replenish cellular NAD(+) supplies. We hypothesize that an insufficient cellular NAD(+) supply is the root cause of metabolic shifts in macrophages. We assert that manipulation of nicotinamide pathways may correct deleterious immune responses. We propose evaluation of nicotinamide (Vitamin B3) and analogues, including isoniazid, nicotinamide mononucleotide and nicotinamide riboside, as potential therapy for infectious causes of sepsis, including COVID-19. Twit Text FOAVip Nicotinamide pathways as the root cause of sepsis - an evolutionary perspective on macrophage energetic shifts ????FEBS J http://www.kidney.de/pget.php?&tw=1&pmid=33686748 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33686748 #FOAvip English Wikipedia <ref>{{Cite pmid|33686748}}</ref> Nicotinamide pathways as the root cause of sepsis - an evolutionary perspective on macrophage energetic shifts #MMPMID33686748 Suchard MS; Savulescu DM FEBS J 2022[Feb]; 289 (4): 955-964 PMID33686748show ga Divergent pathways of macrophage metabolism occur during infection, notably switching between oxidative phosphorylation and aerobic glycolysis (Warburg-like metabolism). Concurrently, macrophages shift between alternate and classical activation. A key enzyme upregulated in alternatively activated macrophages is indoleamine 2,3-dioxygenase, which converts tryptophan to kynurenine for de novo synthesis of nicotinamide. Nicotinamide can be used to replenish cellular NAD(+) supplies. We hypothesize that an insufficient cellular NAD(+) supply is the root cause of metabolic shifts in macrophages. We assert that manipulation of nicotinamide pathways may correct deleterious immune responses. We propose evaluation of nicotinamide (Vitamin B3) and analogues, including isoniazid, nicotinamide mononucleotide and nicotinamide riboside, as potential therapy for infectious causes of sepsis, including COVID-19. |*Energy Metabolism[MESH] |Animals[MESH] |Biological Evolution[MESH] |COVID-19/*complications[MESH] |Humans[MESH] |Macrophages/immunology/*metabolism[MESH] |Niacinamide/*metabolism[MESH]Nicotinamide pathways as the root cause of sepsis - an evolutionary pe(epmc).pdf DeepDyve Pubget Overpricing