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10.1038/s41588-021-00805-2 http://scihub22266oqcxt.onion/10.1038/s41588-021-00805-2 33686287!ä!33686287 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Genet 2021 ; 53 (4): 435-444 Nephropedia Template TP {{tp|p=33686287|t=2021. Genome-wide CRISPR screening identifies TMEM106B as a proviral host factor for SARS-CoV-2 |pdf=|usr=}}{{33686287}} gab.com Text Genome-wide CRISPR screening identifies TMEM106B as a proviral host factor for SARS-CoV-2 JO: Nat Genet http://www.kidney.de/pget.php?&tw=1&pmid=33686287 #FOAvip The ongoing COVID-19 pandemic has caused a global economic and health crisis. To identify host factors essential for coronavirus infection, we performed genome-wide functional genetic screens with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human coronavirus 229E. These screens uncovered virus-specific as well as shared host factors, including TMEM41B and PI3K type 3. We discovered that SARS-CoV-2 requires the lysosomal protein TMEM106B to infect human cell lines and primary lung cells. TMEM106B overexpression enhanced SARS-CoV-2 infection as well as pseudovirus infection, suggesting a role in viral entry. Furthermore, single-cell RNA-sequencing of airway cells from patients with COVID-19 demonstrated that TMEM106B expression correlates with SARS-CoV-2 infection. The present study uncovered a collection of coronavirus host factors that may be exploited to develop drugs against SARS-CoV-2 infection or future zoonotic coronavirus outbreaks. Twit Text FOAVip Genome-wide CRISPR screening identifies TMEM106B as a proviral host factor for SARS-CoV-2 ????Nat Genet http://www.kidney.de/pget.php?&tw=1&pmid=33686287 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33686287 #FOAvip English Wikipedia <ref>{{Cite pmid|33686287}}</ref> Genome-wide CRISPR screening identifies TMEM106B as a proviral host factor for SARS-CoV-2 #MMPMID33686287 Baggen J; Persoons L; Vanstreels E; Jansen S; Van Looveren D; Boeckx B; Geudens V; De Man J; Jochmans D; Wauters J; Wauters E; Vanaudenaerde BM; Lambrechts D; Neyts J; Dallmeier K; Thibaut HJ; Jacquemyn M; Maes P; Daelemans D Nat Genet 2021[Apr]; 53 (4): 435-444 PMID33686287show ga The ongoing COVID-19 pandemic has caused a global economic and health crisis. To identify host factors essential for coronavirus infection, we performed genome-wide functional genetic screens with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human coronavirus 229E. These screens uncovered virus-specific as well as shared host factors, including TMEM41B and PI3K type 3. We discovered that SARS-CoV-2 requires the lysosomal protein TMEM106B to infect human cell lines and primary lung cells. TMEM106B overexpression enhanced SARS-CoV-2 infection as well as pseudovirus infection, suggesting a role in viral entry. Furthermore, single-cell RNA-sequencing of airway cells from patients with COVID-19 demonstrated that TMEM106B expression correlates with SARS-CoV-2 infection. The present study uncovered a collection of coronavirus host factors that may be exploited to develop drugs against SARS-CoV-2 infection or future zoonotic coronavirus outbreaks. |*CRISPR-Cas Systems[MESH] |Bronchoalveolar Lavage Fluid/cytology[MESH] |COVID-19/epidemiology/*genetics/virology[MESH] |Cell Line, Tumor[MESH] |Cells, Cultured[MESH] |Coronavirus 229E, Human/genetics[MESH] |Epidemics[MESH] |Epithelial Cells/virology[MESH] |Gene Expression[MESH] |Genome, Human/*genetics[MESH] |Genome-Wide Association Study/*methods[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Membrane Proteins/*genetics[MESH] |Nerve Tissue Proteins/*genetics[MESH] |Proviruses/physiology[MESH] |SARS-CoV-2/physiology[MESH]Genome-wide CRISPR screening identifies TMEM106B as a proviral host fa(epmc).pdf DeepDyve Pubget Overpricing