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10.1136/heartjnl-2020-318467 http://scihub22266oqcxt.onion/10.1136/heartjnl-2020-318467 33685931!7944416!33685931     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Heart 2021 ; 107 (15): 1226-1232 Nephropedia Template TP {{tp|p=33685931|t=2021. Clinical outcome of COVID-19 in patients with adult congenital heart disease |pdf=|usr=}}{{33685931}} gab.com Text Clinical outcome of COVID-19 in patients with adult congenital heart disease JO: Heart http://www.kidney.de/pget.php?&tw=1&pmid=33685931 #FOAvip AIMS: Patients with adult congenital heart disease (ACHD) are a potentially vulnerable patient cohort in case of COVID-19. Some cardiac defects may be associated with a poor COVID-19 outcome. Risk estimation in ACHD is currently based on expert opinion. The aim of this study was to collect clinical outcome data and to identify risk factors for a complicated course of COVID-19 in patients with ACHD. METHODS: Twenty-five ACHD centres in nine European countries participated in the study. Consecutive patients with ACHD diagnosed with COVID-19 presenting to one of the participating centres between 27 March and 6 June 2020 were included. A complicated disease course was defined as hospitalisation for COVID-19 requiring non-invasive or invasive ventilation and/or inotropic support, or a fatal outcome. RESULTS: Of 105 patients with a mean age of 38+/-13 years (58% women), 13 had a complicated disease course, of whom 5 died. In univariable analysis, age (OR 1.3, 95% CI 1.1 to 1.7, per 5 years), >/=2 comorbidities (OR 7.1, 95% CI 2.1 to 24.5), body mass index of >25 kg/m(2) (OR 7.2, 95% CI 1.9 to 28.3) and cyanotic heart disease (OR 13.2, 95% CI 2.5 to 68.4) were associated with a complicated disease course. In a multivariable logistic regression model, cyanotic heart disease was the most important predictor (OR 60.0, 95% CI 7.6 to 474.0). CONCLUSIONS: Among patients with ACHD, general risk factors (age, obesity and multiple comorbidities) are associated with an increased risk of complicated COVID-19 course. Congenital cardiac defects at particularly high risk were cyanotic lesions, including unrepaired cyanotic defects or Eisenmenger syndrome. Twit Text FOAVip Clinical outcome of COVID-19 in patients with adult congenital heart disease ????Heart http://www.kidney.de/pget.php?&tw=1&pmid=33685931 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33685931 #FOAvip English Wikipedia <ref>{{Cite pmid|33685931}}</ref> Clinical outcome of COVID-19 in patients with adult congenital heart disease #MMPMID33685931 Schwerzmann M; Ruperti-Repilado FJ; Baumgartner H; Bouma B; Bouchardy J; Budts W; Campens L; Chessa M; Del Cerro Marin MJ; Gabriel H; Gallego P; Garcia-Orta R; Gonzalez AE; Jensen AS; Ladouceur M; Miranda-Barrio B; Morissens M; Pasquet A; Rueda J; van den Bosch AE; van der Zwaan HB; Tobler D; Greutmann M Heart 2021[Jul]; 107 (15): 1226-1232 PMID33685931show ga AIMS: Patients with adult congenital heart disease (ACHD) are a potentially vulnerable patient cohort in case of COVID-19. Some cardiac defects may be associated with a poor COVID-19 outcome. Risk estimation in ACHD is currently based on expert opinion. The aim of this study was to collect clinical outcome data and to identify risk factors for a complicated course of COVID-19 in patients with ACHD. METHODS: Twenty-five ACHD centres in nine European countries participated in the study. Consecutive patients with ACHD diagnosed with COVID-19 presenting to one of the participating centres between 27 March and 6 June 2020 were included. A complicated disease course was defined as hospitalisation for COVID-19 requiring non-invasive or invasive ventilation and/or inotropic support, or a fatal outcome. RESULTS: Of 105 patients with a mean age of 38+/-13 years (58% women), 13 had a complicated disease course, of whom 5 died. In univariable analysis, age (OR 1.3, 95% CI 1.1 to 1.7, per 5 years), >/=2 comorbidities (OR 7.1, 95% CI 2.1 to 24.5), body mass index of >25 kg/m(2) (OR 7.2, 95% CI 1.9 to 28.3) and cyanotic heart disease (OR 13.2, 95% CI 2.5 to 68.4) were associated with a complicated disease course. In a multivariable logistic regression model, cyanotic heart disease was the most important predictor (OR 60.0, 95% CI 7.6 to 474.0). CONCLUSIONS: Among patients with ACHD, general risk factors (age, obesity and multiple comorbidities) are associated with an increased risk of complicated COVID-19 course. Congenital cardiac defects at particularly high risk were cyanotic lesions, including unrepaired cyanotic defects or Eisenmenger syndrome. äClinical outcome of COVID-19 in patients with adult congenital heart d(epmc).pdf DeepDyve Pubget Overpricing