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Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Enferm+Infecc+Microbiol+Clin+(Engl+Ed) 2021 ; 40 (10): 546-9 Nephropedia Template TP
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First confirmation of importation and transmission in Spain of the newly identified SARS-CoV-2 B 1 1 7 variant #MMPMID33685741
Buenestado-Serrano S; Recio R; Sola Campoy PJ; Catalan P; Folgueira MD; Villa J; Munoz Gallego I; de la Cueva VM; Melendez MA; Andres Zayas C; Losa-Garcia JE; Goyanes MJ; Fraile Torres A; Von Wermitz A; Fradejas-Villajos I; Del Arco C; Campelo-Gutierrez C; Gonzalez Bodi S; Lopez-Wolf D; Iglesias-Franco H; Perez-Lago L; Arce Arnaez A; Rodriguez Baena E; Ordobas Gavin M; Munoz P; Delgado R; Cardenoso L; Viedma E; Garcia de Viedma D
INTRODUCTION: A newly identified SARS-CoV-2 variant, VOC202012/01 originating lineage B.1.1.7, recently emerged in the United Kingdom. The rapid spread in the UK of this new variant has caused other countries to be vigilant. MATERIAL AND METHODS: We based our initial screening of B.1.1.7 on the dropout of the S gene signal in the TaqPath assay, caused by the 69/70 deletion. Subsequently, we confirmed the B.1.1.7 candidates by whole genome sequencing. RESULTS: We describe the first three imported cases of this variant from London to Madrid, subsequent post-arrival household transmission to three relatives, and the two first cases without epidemiological links to UK. One case required hospitalization. In all cases, drop-out of gene S was correctly associated to the B.1.1.7 variant, as all the corresponding sequences carried the 17 lineage-marker mutations. CONCLUSION: The first identifications of the SARS-CoV-2 B.1.1.7 variant in Spain indicate the role of independent introductions from the UK coexisting with post-arrival transmission in the community, since the early steps of this new variant in our country.