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10.1002/anie.202100345 http://scihub22266oqcxt.onion/10.1002/anie.202100345 33684258!8250721!33684258     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33684258&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Angew+Chem+Int+Ed+Engl 2021 ; 60 (18): 10273-10278 Nephropedia Template TP {{tp|p=33684258|t=2021. Neutralizing Aptamers Block S/RBD-ACE2 Interactions and Prevent Host Cell Infection |pdf=|usr=}}{{33684258}} gab.com Text Neutralizing Aptamers Block S/RBD-ACE2 Interactions and Prevent Host Cell Infection JO: Angew Chem Int Ed Engl http://www.kidney.de/pget.php?&tw=1&pmid=33684258 #FOAvip The receptor-binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 spike (S) protein plays a central role in mediating the first step of virus infection to cause disease: virus binding to angiotensin-converting enzyme 2 (ACE2) receptors on human host cells. Therefore, S/RBD is an ideal target for blocking and neutralization therapies to prevent and treat coronavirus disease 2019 (COVID-19). Using a target-based selection approach, we developed oligonucleotide aptamers containing a conserved sequence motif that specifically targets S/RBD. Synthetic aptamers had high binding affinity for S/RBD-coated virus mimics (K(D) approximately 7 nM) and also blocked interaction of S/RBD with ACE2 receptors (IC(50) approximately 5 nM). Importantly, aptamers were able to neutralize S protein-expressing viral particles and prevent host cell infection, suggesting a promising COVID-19 therapy strategy. Twit Text FOAVip Neutralizing Aptamers Block S/RBD-ACE2 Interactions and Prevent Host Cell Infection ????Angew Chem Int Ed Engl http://www.kidney.de/pget.php?&tw=1&pmid=33684258 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33684258 #FOAvip English Wikipedia <ref>{{Cite pmid|33684258}}</ref> Neutralizing Aptamers Block S/RBD-ACE2 Interactions and Prevent Host Cell Infection #MMPMID33684258 Liu X; Wang YL; Wu J; Qi J; Zeng Z; Wan Q; Chen Z; Manandhar P; Cavener VS; Boyle NR; Fu X; Salazar E; Kuchipudi SV; Kapur V; Zhang X; Umetani M; Sen M; Willson RC; Chen SH; Zu Y Angew Chem Int Ed Engl 2021[Apr]; 60 (18): 10273-10278 PMID33684258show ga The receptor-binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 spike (S) protein plays a central role in mediating the first step of virus infection to cause disease: virus binding to angiotensin-converting enzyme 2 (ACE2) receptors on human host cells. Therefore, S/RBD is an ideal target for blocking and neutralization therapies to prevent and treat coronavirus disease 2019 (COVID-19). Using a target-based selection approach, we developed oligonucleotide aptamers containing a conserved sequence motif that specifically targets S/RBD. Synthetic aptamers had high binding affinity for S/RBD-coated virus mimics (K(D) approximately 7 nM) and also blocked interaction of S/RBD with ACE2 receptors (IC(50) approximately 5 nM). Importantly, aptamers were able to neutralize S protein-expressing viral particles and prevent host cell infection, suggesting a promising COVID-19 therapy strategy. |*COVID-19 Drug Treatment[MESH] |Angiotensin-Converting Enzyme 2/*metabolism[MESH] |Antiviral Agents/chemistry/*pharmacology[MESH] |Aptamers, Nucleotide/chemistry/*pharmacology[MESH] |Base Sequence[MESH] |COVID-19/metabolism[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Protein Interaction Domains and Motifs/drug effects[MESH] |Protein Interaction Maps/drug effects[MESH] |SARS-CoV-2/chemistry/*drug effects/physiology[MESH]Neutralizing Aptamers Block S/RBD-ACE2 Interactions and Prevent Host C(epmc).pdf DeepDyve Pubget Overpricing