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10.1002/anie.202100316 http://scihub22266oqcxt.onion/10.1002/anie.202100316 33683787!8251191!33683787     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Angew+Chem+Int+Ed+Engl 2021 ; 60 (18): 10279-10285 Nephropedia Template TP {{tp|p=33683787|t=2021. A SARS-CoV-2 Spike Binding DNA Aptamer that Inhibits Pseudovirus Infection by an RBD-Independent Mechanism* |pdf=|usr=}}{{33683787}} gab.com Text A SARS-CoV-2 Spike Binding DNA Aptamer that Inhibits Pseudovirus Infection by an RBD-Independent Mechanism* JO: Angew Chem Int Ed Engl http://www.kidney.de/pget.php?&tw=1&pmid=33683787 #FOAvip The receptor binding domain (RBD) of the spike glycoprotein of the coronavirus SARS-CoV-2 (CoV2-S) binds to the human angiotensin-converting enzyme 2 (ACE2) representing the initial contact point for leveraging the infection cascade. We used an automated selection process and identified an aptamer that specifically interacts with CoV2-S. The aptamer does not bind to the RBD of CoV2-S and does not block the interaction of CoV2-S with ACE2. Nevertheless, infection studies revealed potent and specific inhibition of pseudoviral infection by the aptamer. The present study opens up new vistas in developing SARS-CoV2 infection inhibitors, independent of blocking the ACE2 interaction of the virus, and harnesses aptamers as potential drug candidates and tools to disentangle hitherto inaccessible infection modalities, which is of particular interest in light of the increasing number of escape mutants that are currently being reported. Twit Text FOAVip A SARS-CoV-2 Spike Binding DNA Aptamer that Inhibits Pseudovirus Infection by an RBD-Independent Mechanism* ????Angew Chem Int Ed Engl http://www.kidney.de/pget.php?&tw=1&pmid=33683787 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33683787 #FOAvip English Wikipedia <ref>{{Cite pmid|33683787}}</ref> A SARS-CoV-2 Spike Binding DNA Aptamer that Inhibits Pseudovirus Infection by an RBD-Independent Mechanism* #MMPMID33683787 Schmitz A; Weber A; Bayin M; Breuers S; Fieberg V; Famulok M; Mayer G Angew Chem Int Ed Engl 2021[Apr]; 60 (18): 10279-10285 PMID33683787show ga The receptor binding domain (RBD) of the spike glycoprotein of the coronavirus SARS-CoV-2 (CoV2-S) binds to the human angiotensin-converting enzyme 2 (ACE2) representing the initial contact point for leveraging the infection cascade. We used an automated selection process and identified an aptamer that specifically interacts with CoV2-S. The aptamer does not bind to the RBD of CoV2-S and does not block the interaction of CoV2-S with ACE2. Nevertheless, infection studies revealed potent and specific inhibition of pseudoviral infection by the aptamer. The present study opens up new vistas in developing SARS-CoV2 infection inhibitors, independent of blocking the ACE2 interaction of the virus, and harnesses aptamers as potential drug candidates and tools to disentangle hitherto inaccessible infection modalities, which is of particular interest in light of the increasing number of escape mutants that are currently being reported. |*COVID-19 Drug Treatment[MESH] |Angiotensin-Converting Enzyme 2/metabolism[MESH] |Antiviral Agents/chemistry/*pharmacology[MESH] |Aptamers, Nucleotide/chemistry/*pharmacology[MESH] |Binding Sites/drug effects[MESH] |COVID-19/metabolism[MESH] |Drug Discovery[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Protein Binding/drug effects[MESH] |Protein Interaction Domains and Motifs/drug effects[MESH] |SARS-CoV-2/chemistry/*drug effects/physiology[MESH] |SELEX Aptamer Technique[MESH]A SARS-CoV-2 Spike Binding DNA Aptamer that Inhibits Pseudovirus Infec(epmc).pdf DeepDyve Pubget Overpricing