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10.7554/eLife.64330 http://scihub22266oqcxt.onion/10.7554/eLife.64330 33683204!8049742!33683204     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33683204&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Elife 2021 ; 10 (ä): ä Nephropedia Template TP {{tp|p=33683204|t=2021. SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung |pdf=|usr=}}{{33683204}} gab.com Text SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=33683204 #FOAvip Extensive fibrin deposition in the lungs and altered levels of circulating blood coagulation proteins in COVID-19 patients imply local derangement of pathways that limit fibrin formation and/or promote its clearance. We examined transcriptional profiles of bronchoalveolar lavage fluid (BALF) samples to identify molecular mechanisms underlying these coagulopathies. mRNA levels for regulators of the kallikrein-kinin (C1-inhibitor), coagulation (thrombomodulin, endothelial protein C receptor), and fibrinolytic (urokinase and urokinase receptor) pathways were significantly reduced in COVID-19 patients. While transcripts for several coagulation proteins were increased, those encoding tissue factor, the protein that initiates coagulation and whose expression is frequently increased in inflammatory disorders, were not increased in BALF from COVID-19 patients. Our analysis implicates enhanced propagation of coagulation and decreased fibrinolysis as drivers of the coagulopathy in the lungs of COVID-19 patients. Twit Text FOAVip SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=33683204 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33683204 #FOAvip English Wikipedia <ref>{{Cite pmid|33683204}}</ref> SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung #MMPMID33683204 Mast AE; Wolberg AS; Gailani D; Garvin MR; Alvarez C; Miller JI; Aronow B; Jacobson D Elife 2021[Mar]; 10 (ä): ä PMID33683204show ga Extensive fibrin deposition in the lungs and altered levels of circulating blood coagulation proteins in COVID-19 patients imply local derangement of pathways that limit fibrin formation and/or promote its clearance. We examined transcriptional profiles of bronchoalveolar lavage fluid (BALF) samples to identify molecular mechanisms underlying these coagulopathies. mRNA levels for regulators of the kallikrein-kinin (C1-inhibitor), coagulation (thrombomodulin, endothelial protein C receptor), and fibrinolytic (urokinase and urokinase receptor) pathways were significantly reduced in COVID-19 patients. While transcripts for several coagulation proteins were increased, those encoding tissue factor, the protein that initiates coagulation and whose expression is frequently increased in inflammatory disorders, were not increased in BALF from COVID-19 patients. Our analysis implicates enhanced propagation of coagulation and decreased fibrinolysis as drivers of the coagulopathy in the lungs of COVID-19 patients. |*SARS-CoV-2[MESH] |Anticoagulants/metabolism[MESH] |Blood Coagulation/*genetics[MESH] |Bronchoalveolar Lavage Fluid[MESH] |COVID-19/genetics/metabolism/*pathology[MESH] |Endothelial Protein C Receptor/genetics/metabolism[MESH] |Fibrin/*genetics/metabolism[MESH] |Gene Expression[MESH] |Humans[MESH] |Kallikrein-Kinin System/genetics[MESH] |Kallikreins/genetics/metabolism[MESH] |Kinins/genetics/metabolism[MESH] |Lung/metabolism/*pathology[MESH] |RNA, Messenger/metabolism[MESH] |Sequence Analysis, RNA[MESH] |Thrombomodulin/genetics/metabolism[MESH]SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression i(epmc).pdf DeepDyve Pubget Overpricing