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10.1007/s40495-021-00254-9 http://scihub22266oqcxt.onion/10.1007/s40495-021-00254-9 33680715!7921287!33680715     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Pharmacol+Rep 2021 ; 7 (2): 42-48 Nephropedia Template TP {{tp|p=33680715|t=2021. Determination of Potential Drug Candidate Molecules of the Hypericum perforatum for COVID-19 Treatment |pdf=|usr=}}{{33680715}} gab.com Text Determination of Potential Drug Candidate Molecules of the Hypericum perforatum for COVID-19 Treatment JO: Curr Pharmacol Rep http://www.kidney.de/pget.php?&tw=1&pmid=33680715 #FOAvip The novel human coronavirus was firstly emerged in December 2019 in Wuhan, China, and has spread rapidly around the world. There is no known specific effective treatment of COVID-19. The most commonly used agents against this disease both in Turkey and around the world include chloroquine, hydroxychloroquine, lopinavir/ritonavir, favipiravir, and remdesivir. In the study, we investigated the drug potential of molecules that the components of an important medicinal plant Hypericum perforatum by using molecular docking and drug possibility properties of these molecules. The molecular docking results showed that the most stable complex was obtained with COVID-19 main protease and hypericin/isohypericin ligands with - 11 kcal/mol binding energy. Furthermore, ADMET, drug-likeness features of compounds of H. perforatum were investigated using the rules of Lipinski, Veber, and Ghose. According to the results obtained, it has been shown that H. perforatum has the potential to be an effective drug in the COVID-19 pandemic. In the next stage, it is necessary to carry out the clinically necessary reliability studies of these components. It is thought that it can be used for the treatment of COVID-19 if our molecular docking results are found to be in high correlation with clinical studies. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40495-021-00254-9. Twit Text FOAVip Determination of Potential Drug Candidate Molecules of the Hypericum perforatum for COVID-19 Treatment ????Curr Pharmacol Rep http://www.kidney.de/pget.php?&tw=1&pmid=33680715 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33680715 #FOAvip English Wikipedia <ref>{{Cite pmid|33680715}}</ref> Determination of Potential Drug Candidate Molecules of the Hypericum perforatum for COVID-19 Treatment #MMPMID33680715 Yalcin S; Yalcinkaya S; Ercan F Curr Pharmacol Rep 2021[]; 7 (2): 42-48 PMID33680715show ga The novel human coronavirus was firstly emerged in December 2019 in Wuhan, China, and has spread rapidly around the world. There is no known specific effective treatment of COVID-19. The most commonly used agents against this disease both in Turkey and around the world include chloroquine, hydroxychloroquine, lopinavir/ritonavir, favipiravir, and remdesivir. In the study, we investigated the drug potential of molecules that the components of an important medicinal plant Hypericum perforatum by using molecular docking and drug possibility properties of these molecules. The molecular docking results showed that the most stable complex was obtained with COVID-19 main protease and hypericin/isohypericin ligands with - 11 kcal/mol binding energy. Furthermore, ADMET, drug-likeness features of compounds of H. perforatum were investigated using the rules of Lipinski, Veber, and Ghose. According to the results obtained, it has been shown that H. perforatum has the potential to be an effective drug in the COVID-19 pandemic. In the next stage, it is necessary to carry out the clinically necessary reliability studies of these components. It is thought that it can be used for the treatment of COVID-19 if our molecular docking results are found to be in high correlation with clinical studies. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40495-021-00254-9. äDetermination of Potential Drug Candidate Molecules of the Hypericum p(epmc).pdf DeepDyve Pubget Overpricing