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10.3389/fimmu.2021.565625

http://scihub22266oqcxt.onion/10.3389/fimmu.2021.565625
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suck abstract from ncbi

pmid33679730      Front+Immunol 2021 ; 12 (?): 565625
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  • Less Severe Cases of COVID-19 in Sub-Saharan Africa: Could Co-infection or a Recent History of Plasmodium falciparum Infection Be Protective? #MMPMID33679730
  • Kalungi A; Kinyanda E; Akena DH; Kaleebu P; Bisangwa IM
  • Front Immunol 2021[]; 12 (?): 565625 PMID33679730show ga
  • Sub-Saharan Africa has generally experienced few cases and deaths of coronavirus disease 2019 (COVID-19). In addition to other potential explanations for the few cases and deaths of COVID-19 such as the population socio-demographics, early lockdown measures and the possibility of under reporting, we hypothesize in this mini review that individuals with a recent history of malaria infection may be protected against infection or severe form of COVID-19. Given that both the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Plasmodium falciparum (P. falciparum) merozoites bind to the cluster of differentiation 147 (CD147) immunoglobulin, we hypothesize that the immunological memory against P. falciparum merozoites primes SARS-CoV-2 infected cells for early phagocytosis, hence protecting individuals with a recent P. falciparum infection against COVID-19 infection or severity. This mini review therefore discusses the potential biological link between P. falciparum infection and COVID-19 infection or severity and further highlights the importance of CD147 immunoglobulin as an entry point for both SARS-CoV-2 and P. falciparum into host cells.
  • |*COVID-19/epidemiology/immunology[MESH]
  • |*Immunologic Memory[MESH]
  • |*Malaria, Falciparum/epidemiology/immunology[MESH]
  • |Africa South of the Sahara/epidemiology[MESH]
  • |Basigin/*immunology[MESH]
  • |Humans[MESH]
  • |Merozoites/immunology[MESH]
  • |Plasmodium falciparum/*immunology[MESH]
  • |SARS-CoV-2/*immunology[MESH]


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