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10.4081/reumatismo.2020.1333

http://scihub22266oqcxt.onion/10.4081/reumatismo.2020.1333
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33677945!ä!33677945

suck abstract from ncbi


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pmid33677945      Reumatismo 2021 ; 72 (4): 189-196
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  • Vitamin D and disease severity in coronavirus disease 19 (COVID-19) #MMPMID33677945
  • Adami G; Giollo A; Fassio A; Benini C; Bertoldo E; Bertoldo F; Orsolini G; Idolazzi L; Viapiana O; Giannini S; Passeri G; Tacconelli E; Micheletto C; Gatti D; Rossini M
  • Reumatismo 2021[Jan]; 72 (4): 189-196 PMID33677945show ga
  • The role of 25-OH-vitamin D in the assessment of coronavirus disease 19 (COVID-19) has not been investigated. We sought to investigate the prevalence of 25-OH-vitamin D deficiency among COVID-19 patients, and to determine the associations between 25-OH-vitamin D status and the severity of the disease. We have conducted a retrospective observational study of COVID-19 patients admitted to the University of Verona Hospital Trust. Demographic, clinical and biochemical parameters were collected at hospital admission, and serum 25-OH-vitamin D levels were measured. The following outcomes were assessed: arterial partial oxygen pressure (PaO2); C-reactive protein (CRP); length of hospitalization; requirement of oxygen therapy; non-invasive ventilation (NIV); mechanical ventilation; and death. Among 61 patients enrolled, 72.1% was 25-OH-vitamin D deficient (<20 ng/mL) and 57.4% had 25-OHvitamin D <15 ng/mL. Patients with arterial PaO2 <60 mmHg had significantly lower mean 25-OH-vitamin D levels compared to patients with PaO2 >/=60 mmHg (13.3 ng/mL vs 20.4 ng/mL respectively, p=0.03). Vitamin D deficiency was associated with 3-fold higher risk of having arterial pO2 <60 mmHg. 25-OH-vitamin D deficiency was associated with increased CRP and dyspnea. 25-OH-vitamin D deficiency was associated with more severe systemic inflammatory response and respiratory failure in COVID-19 patients.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |C-Reactive Protein/analysis[MESH]
  • |COVID-19/*blood/epidemiology[MESH]
  • |Comorbidity[MESH]
  • |Disease Susceptibility[MESH]
  • |Dyspnea/etiology[MESH]
  • |Female[MESH]
  • |Fibrinogen/analysis[MESH]
  • |Humans[MESH]
  • |Italy/epidemiology[MESH]
  • |Length of Stay/statistics & numerical data[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Oxygen/blood[MESH]
  • |Partial Pressure[MESH]
  • |Prevalence[MESH]
  • |Respiration, Artificial/statistics & numerical data[MESH]
  • |Retrospective Studies[MESH]
  • |Severity of Illness Index[MESH]
  • |Vitamin D Deficiency/blood/epidemiology[MESH]


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