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Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cell 2021 ; 184 (6): 1530-1544 Nephropedia Template TP
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Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care #MMPMID33675692
Pillon NJ; Loos RJF; Marshall SM; Zierath JR
Cell 2021[Mar]; 184 (6): 1530-1544 PMID33675692show ga
The prevalence of type 2 diabetes and obesity has risen dramatically for decades and is expected to rise further, secondary to the growing aging, sedentary population. The strain on global health care is projected to be colossal. This review explores the latest work and emerging ideas related to genetic and environmental factors influencing metabolism. Translational research and clinical applications, including the impact of the COVID-19 pandemic, are highlighted. Looking forward, strategies to personalize all aspects of prevention, management and care are necessary to improve health outcomes and reduce the impact of these metabolic diseases.
|*Pandemics[MESH]
|*SARS-CoV-2[MESH]
|COVID-19/*epidemiology/virology[MESH]
|Circadian Rhythm[MESH]
|Diabetes Mellitus, Type 2/*epidemiology/genetics/metabolism/*therapy[MESH]