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10.1093/molbev/msab060 http://scihub22266oqcxt.onion/10.1093/molbev/msab060 33674876!7989403!33674876     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Biol+Evol 2021 ; 38 (7): 2715-2731 Nephropedia Template TP {{tp|p=33674876|t=2021. Identifying Primate ACE2 Variants That Confer Resistance to SARS-CoV-2 |pdf=|usr=}}{{33674876}} gab.com Text Identifying Primate ACE2 Variants That Confer Resistance to SARS-CoV-2 JO: Mol Biol Evol http://www.kidney.de/pget.php?&tw=1&pmid=33674876 #FOAvip SARS-CoV-2 infects humans through the binding of viral S-protein (spike protein) to human angiotensin I converting enzyme 2 (ACE2). The structure of the ACE2-S-protein complex has been deciphered and we focused on the 27 ACE2 residues that bind to S-protein. From human sequence databases, we identified nine ACE2 variants at ACE2-S-protein binding sites. We used both experimental assays and protein structure analysis to evaluate the effect of each variant on the binding affinity of ACE2 to S-protein. We found one variant causing complete binding disruption, two and three variants, respectively, strongly and mildly reducing the binding affinity, and two variants strongly enhancing the binding affinity. We then collected the ACE2 gene sequences from 57 nonhuman primates. Among the 6 apes and 20 Old World monkeys (OWMs) studied, we found no new variants. In contrast, all 11 New World monkeys (NWMs) studied share four variants each causing a strong reduction in binding affinity, the Philippine tarsier also possesses three such variants, and 18 of the 19 prosimian species studied share one variant causing a strong reduction in binding affinity. Moreover, one OWM and three prosimian variants increased binding affinity by >50%. Based on these findings, we proposed that the common ancestor of primates was strongly resistant to and that of NWMs was completely resistant to SARS-CoV-2 and so is the Philippine tarsier, whereas apes and OWMs, like most humans, are susceptible. This study increases our understanding of the differences in susceptibility to SARS-CoV-2 infection among primates. Twit Text FOAVip Identifying Primate ACE2 Variants That Confer Resistance to SARS-CoV-2 ????Mol Biol Evol http://www.kidney.de/pget.php?&tw=1&pmid=33674876 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33674876 #FOAvip English Wikipedia <ref>{{Cite pmid|33674876}}</ref> Identifying Primate ACE2 Variants That Confer Resistance to SARS-CoV-2 #MMPMID33674876 Bhattacharjee MJ; Lin JJ; Chang CY; Chiou YT; Li TN; Tai CW; Shiu TF; Chen CA; Chou CY; Chakraborty P; Tseng YY; Wang LH; Li WH Mol Biol Evol 2021[Jun]; 38 (7): 2715-2731 PMID33674876show ga SARS-CoV-2 infects humans through the binding of viral S-protein (spike protein) to human angiotensin I converting enzyme 2 (ACE2). The structure of the ACE2-S-protein complex has been deciphered and we focused on the 27 ACE2 residues that bind to S-protein. From human sequence databases, we identified nine ACE2 variants at ACE2-S-protein binding sites. We used both experimental assays and protein structure analysis to evaluate the effect of each variant on the binding affinity of ACE2 to S-protein. We found one variant causing complete binding disruption, two and three variants, respectively, strongly and mildly reducing the binding affinity, and two variants strongly enhancing the binding affinity. We then collected the ACE2 gene sequences from 57 nonhuman primates. Among the 6 apes and 20 Old World monkeys (OWMs) studied, we found no new variants. In contrast, all 11 New World monkeys (NWMs) studied share four variants each causing a strong reduction in binding affinity, the Philippine tarsier also possesses three such variants, and 18 of the 19 prosimian species studied share one variant causing a strong reduction in binding affinity. Moreover, one OWM and three prosimian variants increased binding affinity by >50%. Based on these findings, we proposed that the common ancestor of primates was strongly resistant to and that of NWMs was completely resistant to SARS-CoV-2 and so is the Philippine tarsier, whereas apes and OWMs, like most humans, are susceptible. This study increases our understanding of the differences in susceptibility to SARS-CoV-2 infection among primates. |*COVID-19/genetics/immunology[MESH] |*Peptidyl-Dipeptidase A/genetics/immunology[MESH] |*SARS-CoV-2/genetics/immunology[MESH] |Animals[MESH] |Chlorocebus aethiops[MESH] |Disease Resistance/*genetics[MESH] |Humans[MESH]Identifying Primate ACE2 Variants That Confer Resistance to SARS-CoV-2(epmc).pdf DeepDyve Pubget Overpricing