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10.1038/s41590-021-00902-8 http://scihub22266oqcxt.onion/10.1038/s41590-021-00902-8 33674800!7610739!33674800     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2021 ; 22 (5): 620-626 Nephropedia Template TP {{tp|p=33674800|t=2021. Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection |pdf=|usr=}}{{33674800}} gab.com Text Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33674800 #FOAvip The immune response to SARS-CoV-2 is critical in controlling disease, but there is concern that waning immunity may predispose to reinfection. We analyzed the magnitude and phenotype of the SARS-CoV-2-specific T cell response in 100 donors at 6 months following infection. T cell responses were present by ELISPOT and/or intracellular cytokine staining analysis in all donors and characterized by predominant CD4(+) T cell responses with strong interleukin (IL)-2 cytokine expression. Median T cell responses were 50% higher in donors who had experienced a symptomatic infection, indicating that the severity of primary infection establishes a 'set point' for cellular immunity. T cell responses to spike and nucleoprotein/membrane proteins were correlated with peak antibody levels. Furthermore, higher levels of nucleoprotein-specific T cells were associated with preservation of nucleoprotein-specific antibody level although no such correlation was observed in relation to spike-specific responses. In conclusion, our data are reassuring that functional SARS-CoV-2-specific T cell responses are retained at 6 months following infection. Twit Text FOAVip Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33674800 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33674800 #FOAvip English Wikipedia <ref>{{Cite pmid|33674800}}</ref> Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection #MMPMID33674800 Zuo J; Dowell AC; Pearce H; Verma K; Long HM; Begum J; Aiano F; Amin-Chowdhury Z; Hoschler K; Brooks T; Taylor S; Hewson J; Hallis B; Stapley L; Borrow R; Linley E; Ahmad S; Parker B; Horsley A; Amirthalingam G; Brown K; Ramsay ME; Ladhani S; Moss P Nat Immunol 2021[May]; 22 (5): 620-626 PMID33674800show ga The immune response to SARS-CoV-2 is critical in controlling disease, but there is concern that waning immunity may predispose to reinfection. We analyzed the magnitude and phenotype of the SARS-CoV-2-specific T cell response in 100 donors at 6 months following infection. T cell responses were present by ELISPOT and/or intracellular cytokine staining analysis in all donors and characterized by predominant CD4(+) T cell responses with strong interleukin (IL)-2 cytokine expression. Median T cell responses were 50% higher in donors who had experienced a symptomatic infection, indicating that the severity of primary infection establishes a 'set point' for cellular immunity. T cell responses to spike and nucleoprotein/membrane proteins were correlated with peak antibody levels. Furthermore, higher levels of nucleoprotein-specific T cells were associated with preservation of nucleoprotein-specific antibody level although no such correlation was observed in relation to spike-specific responses. In conclusion, our data are reassuring that functional SARS-CoV-2-specific T cell responses are retained at 6 months following infection. |*Immunity, Cellular[MESH] |Adult[MESH] |Aged[MESH] |Antibodies, Viral/blood[MESH] |Antigens, Viral/*immunology[MESH] |CD4-Positive T-Lymphocytes/*immunology/metabolism/virology[MESH] |CD8-Positive T-Lymphocytes/*immunology/metabolism/virology[MESH] |COVID-19/blood/*immunology/virology[MESH] |Female[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Interleukin-2/blood[MESH] |Male[MESH] |Middle Aged[MESH] |Phenotype[MESH] |SARS-CoV-2/*immunology/pathogenicity[MESH] |Time Factors[MESH]Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months f(epmc).pdf DeepDyve Pubget Overpricing