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10.1038/s42003-021-01829-4 http://scihub22266oqcxt.onion/10.1038/s42003-021-01829-4 33674719!7935909!33674719     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Commun+Biol 2021 ; 4 (1): 290 Nephropedia Template TP {{tp|p=33674719|t=2021. IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection |pdf=|usr=}}{{33674719}} gab.com Text IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection JO: Commun Biol http://www.kidney.de/pget.php?&tw=1&pmid=33674719 #FOAvip SARS-CoV-2 virus has infected more than 92 million people worldwide resulting in the Coronavirus disease 2019 (COVID-19). Using a rhesus macaque model of SARS-CoV-2 infection, we have characterized the transcriptional signatures induced in the lungs of juvenile and old macaques following infection. Genes associated with Interferon (IFN) signaling, neutrophil degranulation and innate immune pathways are significantly induced in macaque infected lungs, while pathways associated with collagen formation are downregulated, as also seen in lungs of macaques with tuberculosis. In COVID-19, increasing age is a significant risk factor for poor prognosis and increased mortality. Type I IFN and Notch signaling pathways are significantly upregulated in lungs of juvenile infected macaques when compared with old infected macaques. These results are corroborated with increased peripheral neutrophil counts and neutrophil lymphocyte ratio in older individuals with COVID-19 disease. Together, our transcriptomic studies have delineated disease pathways that improve our understanding of the immunopathogenesis of COVID-19. Twit Text FOAVip IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection ????Commun Biol http://www.kidney.de/pget.php?&tw=1&pmid=33674719 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33674719 #FOAvip English Wikipedia <ref>{{Cite pmid|33674719}}</ref> IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection #MMPMID33674719 Rosa BA; Ahmed M; Singh DK; Choreno-Parra JA; Cole J; Jimenez-Alvarez LA; Rodriguez-Reyna TS; Singh B; Gonzalez O; Carrion R Jr; Schlesinger LS; Martin J; Zuniga J; Mitreva M; Kaushal D; Khader SA Commun Biol 2021[Mar]; 4 (1): 290 PMID33674719show ga SARS-CoV-2 virus has infected more than 92 million people worldwide resulting in the Coronavirus disease 2019 (COVID-19). Using a rhesus macaque model of SARS-CoV-2 infection, we have characterized the transcriptional signatures induced in the lungs of juvenile and old macaques following infection. Genes associated with Interferon (IFN) signaling, neutrophil degranulation and innate immune pathways are significantly induced in macaque infected lungs, while pathways associated with collagen formation are downregulated, as also seen in lungs of macaques with tuberculosis. In COVID-19, increasing age is a significant risk factor for poor prognosis and increased mortality. Type I IFN and Notch signaling pathways are significantly upregulated in lungs of juvenile infected macaques when compared with old infected macaques. These results are corroborated with increased peripheral neutrophil counts and neutrophil lymphocyte ratio in older individuals with COVID-19 disease. Together, our transcriptomic studies have delineated disease pathways that improve our understanding of the immunopathogenesis of COVID-19. |*Cell Degranulation[MESH] |*SARS-CoV-2[MESH] |Aged[MESH] |Animals[MESH] |CD36 Antigens/physiology[MESH] |COVID-19/etiology/*immunology[MESH] |Collagen/metabolism[MESH] |Disease Models, Animal[MESH] |Female[MESH] |Gene Expression Regulation[MESH] |Humans[MESH] |Interferons/*physiology[MESH] |Lung/metabolism[MESH] |Macaca mulatta[MESH] |Male[MESH] |Middle Aged[MESH] |Neutrophils/*physiology[MESH] |Receptors, Notch/physiology[MESH] |Signal Transduction/physiology[MESH] |Transforming Growth Factor beta/physiology[MESH]IFN signaling and neutrophil degranulation transcriptional signatures (epmc).pdf DeepDyve Pubget Overpricing