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10.1126/sciadv.abf2467 http://scihub22266oqcxt.onion/10.1126/sciadv.abf2467 33674317!7935365!33674317     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Adv 2021 ; 7 (10): ä Nephropedia Template TP {{tp|p=33674317|t=2021. Longitudinal antibody repertoire in "mild" versus "severe" COVID-19 patients reveals immune markers associated with disease severity and resolution |pdf=|usr=}}{{33674317}} gab.com Text Longitudinal antibody repertoire in "mild" versus "severe" COVID-19 patients reveals immune markers associated with disease severity and resolution JO: Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=33674317 #FOAvip Limited knowledge exists on immune markers associated with disease severity or recovery in patients with coronavirus disease 2019 (COVID-19). Here, we elucidated longitudinal evolution of SARS-CoV-2 antibody repertoire in patients with acute COVID-19. Differential kinetics was observed for immunoglobulin M (IgM)/IgG/IgA epitope diversity, antibody binding, and affinity maturation in "severe" versus "mild" COVID-19 patients. IgG profile demonstrated immunodominant antigenic sequences encompassing fusion peptide and receptor binding domain (RBD) in patients with mild COVID-19 who recovered early compared with "fatal" COVID-19 patients. In patients with severe COVID-19, high-titer IgA were observed, primarily against RBD, especially in patients who succumbed to SARS-CoV-2 infection. The patients with mild COVID-19 showed marked increase in antibody affinity maturation to prefusion SARS-CoV-2 spike that associated with faster recovery from COVID-19. This study revealed antibody markers associated with disease severity and resolution of clinical disease that could inform development and evaluation of effective immune-based countermeasures against COVID-19. Twit Text FOAVip Longitudinal antibody repertoire in "mild" versus "severe" COVID-19 patients reveals immune markers associated with disease severity and resolution ????Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=33674317 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33674317 #FOAvip English Wikipedia <ref>{{Cite pmid|33674317}}</ref> Longitudinal antibody repertoire in "mild" versus "severe" COVID-19 patients reveals immune markers associated with disease severity and resolution #MMPMID33674317 Ravichandran S; Lee Y; Grubbs G; Coyle EM; Klenow L; Akasaka O; Koga M; Adachi E; Saito M; Nakachi I; Ogura T; Baba R; Ito M; Kiso M; Yasuhara A; Yamada S; Sakai-Tagawa Y; Iwatsuki-Horimoto K; Imai M; Yamayoshi S; Yotsuyanagi H; Kawaoka Y; Khurana S Sci Adv 2021[Mar]; 7 (10): ä PMID33674317show ga Limited knowledge exists on immune markers associated with disease severity or recovery in patients with coronavirus disease 2019 (COVID-19). Here, we elucidated longitudinal evolution of SARS-CoV-2 antibody repertoire in patients with acute COVID-19. Differential kinetics was observed for immunoglobulin M (IgM)/IgG/IgA epitope diversity, antibody binding, and affinity maturation in "severe" versus "mild" COVID-19 patients. IgG profile demonstrated immunodominant antigenic sequences encompassing fusion peptide and receptor binding domain (RBD) in patients with mild COVID-19 who recovered early compared with "fatal" COVID-19 patients. In patients with severe COVID-19, high-titer IgA were observed, primarily against RBD, especially in patients who succumbed to SARS-CoV-2 infection. The patients with mild COVID-19 showed marked increase in antibody affinity maturation to prefusion SARS-CoV-2 spike that associated with faster recovery from COVID-19. This study revealed antibody markers associated with disease severity and resolution of clinical disease that could inform development and evaluation of effective immune-based countermeasures against COVID-19. |*Severity of Illness Index[MESH] |Antibodies, Viral/*blood/*immunology[MESH] |Antibody Affinity/immunology[MESH] |Antibody Formation/immunology[MESH] |Antigens, Viral/*immunology[MESH] |Biomarkers/*blood[MESH] |COVID-19/blood/*immunology/*pathology/virology[MESH] |Cytokines/blood[MESH] |HEK293 Cells[MESH] |Hospitalization[MESH] |Humans[MESH] |Immunoglobulin Class Switching[MESH] |Kinetics[MESH] |Neutralization Tests[MESH] |Protein Binding[MESH] |Protein Domains[MESH] |SARS-CoV-2/*physiology[MESH] |Spike Glycoprotein, Coronavirus/chemistry/immunology[MESH]Longitudinal antibody repertoire in "mild" versus "severe" COVID-19 pa(epmc).pdf DeepDyve Pubget Overpricing