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10.1128/JCM.01418-20 http://scihub22266oqcxt.onion/10.1128/JCM.01418-20 33674284!8091857!33674284     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Microbiol 2021 ; 59 (5): ä Nephropedia Template TP {{tp|p=33674284|t=2021. Evaluation of Specimen Types and Saliva Stabilization Solutions for SARS-CoV-2 Testing |pdf=|usr=}}{{33674284}} gab.com Text Evaluation of Specimen Types and Saliva Stabilization Solutions for SARS-CoV-2 Testing JO: J Clin Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=33674284 #FOAvip Identifying SARS-CoV-2 infections through aggressive diagnostic testing remains critical to tracking and curbing the spread of the COVID-19 pandemic. Collection of nasopharyngeal swabs (NPS), the preferred sample type for SARS-CoV-2 detection, has become difficult due to the dramatic increase in testing and consequent supply strain. Therefore, alternative specimen types have been investigated that provide similar detection sensitivity with reduced health care exposure and the potential for self-collection. In this study, the detection sensitivity of SARS-CoV-2 in nasal swabs (NS) and saliva was compared to that of NPS using matched specimens from two outpatient cohorts in New York State (total n = 463). The first cohort showed only a 5.4% positivity, but the second cohort (n = 227) had a positivity rate of 41%, with sensitivity in NPS, NS, and saliva of 97.9%, 87.1%, and 87.1%, respectively. Whether the reduced sensitivity of NS or saliva is acceptable must be assessed in the settings where they are used. However, we sought to improve on it by validating a method to mix the two sample types, as the combination of nasal swab and saliva resulted in 94.6% SARS-CoV-2 detection sensitivity. Spiking experiments showed that combining them did not adversely affect the detection sensitivity in either. Virus stability in saliva was also investigated, with and without the addition of commercially available stabilizing solutions. The virus was stable in saliva at both 4 degrees C and room temperature for up to 7 days. The addition of stabilizing solutions did not enhance stability and, in some situations, reduced detectable virus levels. Twit Text FOAVip Evaluation of Specimen Types and Saliva Stabilization Solutions for SARS-CoV-2 Testing ????J Clin Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=33674284 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33674284 #FOAvip English Wikipedia <ref>{{Cite pmid|33674284}}</ref> Evaluation of Specimen Types and Saliva Stabilization Solutions for SARS-CoV-2 Testing #MMPMID33674284 Griesemer SB; Van Slyke G; Ehrbar D; Strle K; Yildirim T; Centurioni DA; Walsh AC; Chang AK; Waxman MJ; St George K J Clin Microbiol 2021[Apr]; 59 (5): ä PMID33674284show ga Identifying SARS-CoV-2 infections through aggressive diagnostic testing remains critical to tracking and curbing the spread of the COVID-19 pandemic. Collection of nasopharyngeal swabs (NPS), the preferred sample type for SARS-CoV-2 detection, has become difficult due to the dramatic increase in testing and consequent supply strain. Therefore, alternative specimen types have been investigated that provide similar detection sensitivity with reduced health care exposure and the potential for self-collection. In this study, the detection sensitivity of SARS-CoV-2 in nasal swabs (NS) and saliva was compared to that of NPS using matched specimens from two outpatient cohorts in New York State (total n = 463). The first cohort showed only a 5.4% positivity, but the second cohort (n = 227) had a positivity rate of 41%, with sensitivity in NPS, NS, and saliva of 97.9%, 87.1%, and 87.1%, respectively. Whether the reduced sensitivity of NS or saliva is acceptable must be assessed in the settings where they are used. However, we sought to improve on it by validating a method to mix the two sample types, as the combination of nasal swab and saliva resulted in 94.6% SARS-CoV-2 detection sensitivity. Spiking experiments showed that combining them did not adversely affect the detection sensitivity in either. Virus stability in saliva was also investigated, with and without the addition of commercially available stabilizing solutions. The virus was stable in saliva at both 4 degrees C and room temperature for up to 7 days. The addition of stabilizing solutions did not enhance stability and, in some situations, reduced detectable virus levels. |*COVID-19 Testing[MESH] |COVID-19/*diagnosis[MESH] |Humans[MESH] |Nasopharynx/virology[MESH] |New York[MESH] |Pandemics[MESH] |SARS-CoV-2/isolation & purification[MESH] |Saliva/*virology[MESH] |Sensitivity and Specificity[MESH] |Specimen Handling/*methods[MESH]Evaluation of Specimen Types and Saliva Stabilization Solutions for SA(epmc).pdf DeepDyve Pubget Overpricing