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10.3390/molecules26041191 http://scihub22266oqcxt.onion/10.3390/molecules26041191 33672163!7927139!33672163     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Molecules 2021 ; 26 (4): ä Nephropedia Template TP {{tp|p=33672163|t=2021. Therapeutic Intervention of COVID-19 by Natural Products: A Population-Specific Survey Directed Approach |pdf=|usr=}}{{33672163}} gab.com Text Therapeutic Intervention of COVID-19 by Natural Products: A Population-Specific Survey Directed Approach JO: Molecules http://www.kidney.de/pget.php?&tw=1&pmid=33672163 #FOAvip To date very few promising leads from natural products (NP) secondary metabolites with antiviral and immunomodulatory properties have been identified for promising/potential intervention for COVID-19. Using in-silico docking studies and genome based various molecular targets, and their in vitro anti-SARS CoV-2 activities against whole cell and/or selected protein targets, we select a few compounds of interest, which can be used as potential leads to counteract effects of uncontrolled innate immune responses, in particular those related to the cytokine storm. A critical factor for prevention and treatment of SARS-CoV-2 infection relates to factors independent of viral infection or host response. They include population-related variables such as concurrent comorbidities and genetic factors critically relevant to COVID-19 health disparities. We discuss population risk factors related to SARS-CoV-2. In addition, we focus on virulence related to glucose-6-phosphate dehydrogenase deficiency (G6PDd), the most common human enzymopathy. Review of data on the response of individuals and communities with high prevalence of G6PDd to NP, prompts us to propose the rationale for a population-specific management approach to rationalize design of therapeutic interventions of SARS-CoV-2 infection, based on use of NP. This strategy may lead to personalized approaches and improve disease-related outcomes. Twit Text FOAVip Therapeutic Intervention of COVID-19 by Natural Products: A Population-Specific Survey Directed Approach ????Molecules http://www.kidney.de/pget.php?&tw=1&pmid=33672163 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33672163 #FOAvip English Wikipedia <ref>{{Cite pmid|33672163}}</ref> Therapeutic Intervention of COVID-19 by Natural Products: A Population-Specific Survey Directed Approach #MMPMID33672163 Gomez CR; Espinoza I; Faruque FS; Hasan MM; Rahman KM; Walker LA; Muhammad I Molecules 2021[Feb]; 26 (4): ä PMID33672163show ga To date very few promising leads from natural products (NP) secondary metabolites with antiviral and immunomodulatory properties have been identified for promising/potential intervention for COVID-19. Using in-silico docking studies and genome based various molecular targets, and their in vitro anti-SARS CoV-2 activities against whole cell and/or selected protein targets, we select a few compounds of interest, which can be used as potential leads to counteract effects of uncontrolled innate immune responses, in particular those related to the cytokine storm. A critical factor for prevention and treatment of SARS-CoV-2 infection relates to factors independent of viral infection or host response. They include population-related variables such as concurrent comorbidities and genetic factors critically relevant to COVID-19 health disparities. We discuss population risk factors related to SARS-CoV-2. In addition, we focus on virulence related to glucose-6-phosphate dehydrogenase deficiency (G6PDd), the most common human enzymopathy. Review of data on the response of individuals and communities with high prevalence of G6PDd to NP, prompts us to propose the rationale for a population-specific management approach to rationalize design of therapeutic interventions of SARS-CoV-2 infection, based on use of NP. This strategy may lead to personalized approaches and improve disease-related outcomes. |*Biological Products/chemistry/therapeutic use[MESH] |*COVID-19 Drug Treatment[MESH] |*SARS-CoV-2[MESH] |Antiviral Agents/chemistry/therapeutic use[MESH] |COVID-19/epidemiology[MESH] |Glucosephosphate Dehydrogenase Deficiency/drug therapy/epidemiology[MESH]Therapeutic Intervention of COVID-19 by Natural Products: A Population(epmc).pdf DeepDyve Pubget Overpricing