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10.3390/antiox10020293 http://scihub22266oqcxt.onion/10.3390/antiox10020293 33672062!7919463!33672062     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33672062&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Antioxidants+(Basel) 2021 ; 10 (2): ? Nephropedia Template TP {{tp|p=33672062|t=2021. Lipotoxic Impairment of Mitochondrial Function in beta-Cells: A Review |pdf=|usr=}}{{33672062}} gab.com Text Lipotoxic Impairment of Mitochondrial Function in beta-Cells: A Review JO: Antioxidants (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=33672062 #FOAvip Lipotoxicity is a major contributor to type 2 diabetes mainly promoting mitochondrial dysfunction. Lipotoxic stress is mediated by elevated levels of free fatty acids through various mechanisms and pathways. Impaired peroxisome proliferator-activated receptor (PPAR) signaling, enhanced oxidative stress levels, and uncoupling of the respiratory chain result in ATP deficiency, while beta-cell viability can be severely impaired by lipotoxic modulation of PI3K/Akt and mitogen-activated protein kinase (MAPK)/extracellular-signal-regulated kinase (ERK) pathways. However, fatty acids are physiologically required for an unimpaired beta-cell function. Thus, preparation, concentration, and treatment duration determine whether the outcome is beneficial or detrimental when fatty acids are employed in experimental setups. Further, ageing is a crucial contributor to beta-cell decay. Cellular senescence is connected to loss of function in beta-cells and can further be promoted by lipotoxicity. The potential benefit of nutrients has been broadly investigated, and particularly polyphenols were shown to be protective against both lipotoxicity and cellular senescence, maintaining the physiology of beta-cells. Positive effects on blood glucose regulation, mitigation of oxidative stress by radical scavenging properties or regulation of antioxidative enzymes, and modulation of apoptotic factors were reported. This review summarizes the significance of lipotoxicity and cellular senescence for mitochondrial dysfunction in the pancreatic beta-cell and outlines potential beneficial effects of plant-based nutrients by the example of polyphenols. Twit Text FOAVip Lipotoxic Impairment of Mitochondrial Function in beta-Cells: A Review ????Antioxidants (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=33672062 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33672062 #FOAvip English Wikipedia <ref>{{Cite pmid|33672062}}</ref> Lipotoxic Impairment of Mitochondrial Function in beta-Cells: A Review #MMPMID33672062 Romer A; Linn T; Petry SF Antioxidants (Basel) 2021[Feb]; 10 (2): ? PMID33672062show ga Lipotoxicity is a major contributor to type 2 diabetes mainly promoting mitochondrial dysfunction. Lipotoxic stress is mediated by elevated levels of free fatty acids through various mechanisms and pathways. Impaired peroxisome proliferator-activated receptor (PPAR) signaling, enhanced oxidative stress levels, and uncoupling of the respiratory chain result in ATP deficiency, while beta-cell viability can be severely impaired by lipotoxic modulation of PI3K/Akt and mitogen-activated protein kinase (MAPK)/extracellular-signal-regulated kinase (ERK) pathways. However, fatty acids are physiologically required for an unimpaired beta-cell function. Thus, preparation, concentration, and treatment duration determine whether the outcome is beneficial or detrimental when fatty acids are employed in experimental setups. Further, ageing is a crucial contributor to beta-cell decay. Cellular senescence is connected to loss of function in beta-cells and can further be promoted by lipotoxicity. The potential benefit of nutrients has been broadly investigated, and particularly polyphenols were shown to be protective against both lipotoxicity and cellular senescence, maintaining the physiology of beta-cells. Positive effects on blood glucose regulation, mitigation of oxidative stress by radical scavenging properties or regulation of antioxidative enzymes, and modulation of apoptotic factors were reported. This review summarizes the significance of lipotoxicity and cellular senescence for mitochondrial dysfunction in the pancreatic beta-cell and outlines potential beneficial effects of plant-based nutrients by the example of polyphenols. ?Lipotoxic Impairment of Mitochondrial Function in beta-Cells: A Review(epmc).pdf DeepDyve Pubget Overpricing