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10.3390/life11020144

http://scihub22266oqcxt.onion/10.3390/life11020144
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33671893!7918959!33671893
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suck abstract from ncbi


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pmid33671893      Life+(Basel) 2021 ; 11 (2): ä
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  • The Road towards Polyclonal Anti-SARS-CoV-2 Immunoglobulins (Hyperimmune Serum) for Passive Immunization in COVID-19 #MMPMID33671893
  • Focosi D; Tuccori M; Franchini M
  • Life (Basel) 2021[Feb]; 11 (2): ä PMID33671893show ga
  • Effective treatments specific for COVID-19 are still lacking. In the setting of passive immunotherapies based on neutralizing antibodies (nAbs), randomized controlled trials of COVID-19 convalescent plasma (CCP) anti-SARS-CoV-2 Spike protein monoclonal antibodies (mAb), which have been granted emergency use authorization, have suggested benefit in early disease course (less than 72 hours from symptoms and seronegative). Meanwhile, polyclonal immunoglobulins (i.e., hyperimmune serum), derived either from CCP donations or from animals immunized with SARS-CoV-2 antigens, are likely to become the next nAb-derived candidate. We here discuss the pros and cons of hyperimmune serum versus CCP and mAb, and summarize the ongoing clinical trials of COVID-19 hyperimmune sera.
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