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10.3390/ijms22052417 http://scihub22266oqcxt.onion/10.3390/ijms22052417 33670859!7957472!33670859     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2021 ; 22 (5): ä Nephropedia Template TP {{tp|p=33670859|t=2021. Capsid and Genome Modification Strategies to Reduce the Immunogenicity of Adenoviral Vectors |pdf=|usr=}}{{33670859}} gab.com Text Capsid and Genome Modification Strategies to Reduce the Immunogenicity of Adenoviral Vectors JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=33670859 #FOAvip Adenovirus-based gene transfer vectors are the most frequently used vector type in gene therapy clinical trials to date, and they play an important role as genetic vaccine candidates during the ongoing SARS-CoV-2 pandemic. Immediately upon delivery, adenovirus-based vectors exhibit multiple complex vector-host interactions and induce innate and adaptive immune responses. This can severely limit their safety and efficacy, particularly after delivery through the blood stream. In this review article we summarize two strategies to modulate Ad vector-induced immune responses: extensive genomic and chemical capsid modifications. Both strategies have shown beneficial effects in a number of preclinical studies while potential synergistic effects warrant further investigations. Twit Text FOAVip Capsid and Genome Modification Strategies to Reduce the Immunogenicity of Adenoviral Vectors ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=33670859 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33670859 #FOAvip English Wikipedia <ref>{{Cite pmid|33670859}}</ref> Capsid and Genome Modification Strategies to Reduce the Immunogenicity of Adenoviral Vectors #MMPMID33670859 Kreppel F; Hagedorn C Int J Mol Sci 2021[Feb]; 22 (5): ä PMID33670859show ga Adenovirus-based gene transfer vectors are the most frequently used vector type in gene therapy clinical trials to date, and they play an important role as genetic vaccine candidates during the ongoing SARS-CoV-2 pandemic. Immediately upon delivery, adenovirus-based vectors exhibit multiple complex vector-host interactions and induce innate and adaptive immune responses. This can severely limit their safety and efficacy, particularly after delivery through the blood stream. In this review article we summarize two strategies to modulate Ad vector-induced immune responses: extensive genomic and chemical capsid modifications. Both strategies have shown beneficial effects in a number of preclinical studies while potential synergistic effects warrant further investigations. |Adenoviridae/*genetics/*immunology[MESH] |Animals[MESH] |COVID-19[MESH] |COVID-19 Vaccines/immunology[MESH] |Capsid Proteins/genetics[MESH] |Capsid/*immunology[MESH] |Genetic Vectors/*genetics/*immunology[MESH] |Humans[MESH] |Immunity[MESH] |Immunogenicity, Vaccine[MESH]Capsid and Genome Modification Strategies to Reduce the Immunogenicity(epmc).pdf DeepDyve Pubget Overpricing