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10.3390/v13020333 http://scihub22266oqcxt.onion/10.3390/v13020333 33670023!7926959!33670023     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Viruses 2021 ; 13 (2): ä Nephropedia Template TP {{tp|p=33670023|t=2021. Rational Design of a Pan-Coronavirus Vaccine Based on Conserved CTL Epitopes |pdf=|usr=}}{{33670023}} gab.com Text Rational Design of a Pan-Coronavirus Vaccine Based on Conserved CTL Epitopes JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=33670023 #FOAvip With the rapid global spread of the Coronavirus Disease 2019 (COVID-19) pandemic, a safe and effective vaccine against human coronaviruses (HCoVs) is believed to be a top priority in the field of public health. Due to the frequent outbreaks of different HCoVs, the development of a pan-HCoVs vaccine is of great value to biomedical science. The antigen design is a key prerequisite for vaccine efficacy, and we therefore developed a novel antigen with broad coverage based on the genetic algorithm of mosaic strategy. The designed antigen has a potentially broad coverage of conserved cytotoxic T lymphocyte (CTL) epitopes to the greatest extent, including the existing epitopes from all reported HCoV sequences (HCoV-NL63, HCoV-229E, HCoV-OC43, HCoV-HKU1, SARS-CoV, MERS-CoV, and SARS-CoV-2). This novel antigen is expected to induce strong CTL responses with broad coverage by targeting conserved epitopes against multiple coronaviruses. Twit Text FOAVip Rational Design of a Pan-Coronavirus Vaccine Based on Conserved CTL Epitopes ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=33670023 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33670023 #FOAvip English Wikipedia <ref>{{Cite pmid|33670023}}</ref> Rational Design of a Pan-Coronavirus Vaccine Based on Conserved CTL Epitopes #MMPMID33670023 Li M; Zeng J; Li R; Wen Z; Cai Y; Wallin J; Shu Y; Du X; Sun C Viruses 2021[Feb]; 13 (2): ä PMID33670023show ga With the rapid global spread of the Coronavirus Disease 2019 (COVID-19) pandemic, a safe and effective vaccine against human coronaviruses (HCoVs) is believed to be a top priority in the field of public health. Due to the frequent outbreaks of different HCoVs, the development of a pan-HCoVs vaccine is of great value to biomedical science. The antigen design is a key prerequisite for vaccine efficacy, and we therefore developed a novel antigen with broad coverage based on the genetic algorithm of mosaic strategy. The designed antigen has a potentially broad coverage of conserved cytotoxic T lymphocyte (CTL) epitopes to the greatest extent, including the existing epitopes from all reported HCoV sequences (HCoV-NL63, HCoV-229E, HCoV-OC43, HCoV-HKU1, SARS-CoV, MERS-CoV, and SARS-CoV-2). This novel antigen is expected to induce strong CTL responses with broad coverage by targeting conserved epitopes against multiple coronaviruses. |Coronavirus Infections/*prevention & control[MESH] |Epitopes, T-Lymphocyte/*immunology[MESH] |Humans[MESH] |Pandemics[MESH] |T-Lymphocytes, Cytotoxic/immunology[MESH] |Viral Proteins/*immunology[MESH]Rational Design of a Pan-Coronavirus Vaccine Based on Conserved CTL Ep(epmc).pdf DeepDyve Pubget Overpricing