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10.3390/v13020317

http://scihub22266oqcxt.onion/10.3390/v13020317
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33669550!7922679!33669550
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suck abstract from ncbi

pmid33669550      Viruses 2021 ; 13 (2): ä
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  • Viral Vectors for COVID-19 Vaccine Development #MMPMID33669550
  • Lundstrom K
  • Viruses 2021[Feb]; 13 (2): ä PMID33669550show ga
  • Vaccine development against SARS-CoV-2 has been fierce due to the devastating COVID-19 pandemic and has included all potential approaches for providing the global community with safe and efficient vaccine candidates in the shortest possible timeframe. Viral vectors have played a central role especially using adenovirus-based vectors. Additionally, other viral vectors based on vaccinia viruses, measles viruses, rhabdoviruses, influenza viruses and lentiviruses have been subjected to vaccine development. Self-amplifying RNA virus vectors have been utilized for lipid nanoparticle-based delivery of RNA as COVID-19 vaccines. Several adenovirus-based vaccine candidates have elicited strong immune responses in immunized animals and protection against challenges in mice and primates has been achieved. Moreover, adenovirus-based vaccine candidates have been subjected to phase I to III clinical trials. Recently, the simian adenovirus-based ChAdOx1 vector expressing the SARS-CoV-2 S spike protein was approved for use in humans in the UK.
  • |*COVID-19 Vaccines[MESH]
  • |Adenoviridae/*immunology[MESH]
  • |Animals[MESH]
  • |Antibodies, Viral/immunology[MESH]
  • |COVID-19/*prevention & control[MESH]
  • |Clinical Trials as Topic[MESH]
  • |Genetic Vectors/*immunology[MESH]
  • |Humans[MESH]
  • |Mice[MESH]
  • |Pandemics[MESH]
  • |RNA, Viral/*immunology[MESH]


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