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10.1016/j.bioorg.2021.104767 http://scihub22266oqcxt.onion/10.1016/j.bioorg.2021.104767 33667900!7903152!33667900     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Bioorg+Chem 2021 ; 110 (ä): 104767 Nephropedia Template TP {{tp|p=33667900|t=2021. Discovery of novel inhibitors against main protease (Mpro) of SARS-CoV-2 via virtual screening and biochemical evaluation |pdf=|usr=}}{{33667900}} gab.com Text Discovery of novel inhibitors against main protease (Mpro) of SARS-CoV-2 via virtual screening and biochemical evaluation JO: Bioorg Chem http://www.kidney.de/pget.php?&tw=1&pmid=33667900 #FOAvip SARS-CoV-2 is the pathogen that caused the global COVID-19 outbreak in 2020. Promising progress has been made in developing vaccines and antiviral drugs. Antivirals medicines are necessary complements of vaccines for post-infection treatment. The main protease (Mpro) is an extremely important protease in the reproduction process of coronaviruses which cleaves pp1ab over more than 11 cleavage sites. In this work, two active main protease inhibitors were found via docking-based virtual screening and bioassay. The IC(50) of compound VS10 was 0.20 muM, and the IC(50) of compound VS12 was 1.89 muM. The finding in this work can be helpful to understand the interactions of main protease and inhibitors. The active candidates could be potential lead compounds for future drug design. Twit Text FOAVip Discovery of novel inhibitors against main protease (Mpro) of SARS-CoV-2 via virtual screening and biochemical evaluation ????Bioorg Chem http://www.kidney.de/pget.php?&tw=1&pmid=33667900 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33667900 #FOAvip English Wikipedia <ref>{{Cite pmid|33667900}}</ref> Discovery of novel inhibitors against main protease (Mpro) of SARS-CoV-2 via virtual screening and biochemical evaluation #MMPMID33667900 Guo S; Xie H; Lei Y; Liu B; Zhang L; Xu Y; Zuo Z Bioorg Chem 2021[May]; 110 (ä): 104767 PMID33667900show ga SARS-CoV-2 is the pathogen that caused the global COVID-19 outbreak in 2020. Promising progress has been made in developing vaccines and antiviral drugs. Antivirals medicines are necessary complements of vaccines for post-infection treatment. The main protease (Mpro) is an extremely important protease in the reproduction process of coronaviruses which cleaves pp1ab over more than 11 cleavage sites. In this work, two active main protease inhibitors were found via docking-based virtual screening and bioassay. The IC(50) of compound VS10 was 0.20 muM, and the IC(50) of compound VS12 was 1.89 muM. The finding in this work can be helpful to understand the interactions of main protease and inhibitors. The active candidates could be potential lead compounds for future drug design. |*Drug Discovery[MESH] |Antiviral Agents/*pharmacology[MESH] |Coronavirus 3C Proteases/*antagonists & inhibitors[MESH] |Drug Evaluation, Preclinical[MESH] |Humans[MESH] |Molecular Docking Simulation[MESH] |Protease Inhibitors/chemistry/*pharmacology[MESH]Discovery of novel inhibitors against main protease (Mpro) of SARS-CoV(epmc).pdf DeepDyve Pubget Overpricing