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10.1016/j.meegid.2021.104796 http://scihub22266oqcxt.onion/10.1016/j.meegid.2021.104796 33667722!7925239!33667722     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Infect+Genet+Evol 2021 ; 91 (ä): 104796 Nephropedia Template TP {{tp|p=33667722|t=2021. Different selection dynamics of S and RdRp between SARS-CoV-2 genomes with and without the dominant mutations |pdf=|usr=}}{{33667722}} gab.com Text Different selection dynamics of S and RdRp between SARS-CoV-2 genomes with and without the dominant mutations JO: Infect Genet Evol http://www.kidney.de/pget.php?&tw=1&pmid=33667722 #FOAvip SARS-CoV-2 is a betacoronavirus responsible for the COVID-19 pandemic that has affected millions of people worldwide. Pharmaceutical research against COVID-19 and the most frequently used tests for SARS-CoV-2 both depend on the genomic and peptide sequences of the virus for their robustness. Therefore, understanding the mutation rates and content of the virus is critical. Two key proteins for SARS-CoV-2 infection and replication are the S protein, responsible for viral entry into the cells, and RdRp, the RNA polymerase responsible for replicating the viral genome. Due to their roles in the viral cycle, these proteins are crucial for the fitness and infectiousness of the virus. Our previous findings had shown that the two most frequently observed mutations in the SARS-CoV-2 genome, 14408C>T in the RdRp coding region, and 23403A>G in the S gene, are correlated with higher mutation density over time. In this study, we further detail the selection dynamics and the mutation rates of SARS-CoV-2 genes, comparing them between isolates carrying both mutations, and isolates carrying neither. We find that the S gene and the RdRp coding region show the highest variance between the genotypes, and their selection dynamics contrast each other over time. The S gene displays higher tolerance for positive selection in mutant isolates early during the appearance of the double mutant genotype, and undergoes increasing negative selection over time, whereas the RdRp region in the mutant isolates shows strong negative selection throughout the pandemic. Twit Text FOAVip Different selection dynamics of S and RdRp between SARS-CoV-2 genomes with and without the dominant mutations ????Infect Genet Evol http://www.kidney.de/pget.php?&tw=1&pmid=33667722 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33667722 #FOAvip English Wikipedia <ref>{{Cite pmid|33667722}}</ref> Different selection dynamics of S and RdRp between SARS-CoV-2 genomes with and without the dominant mutations #MMPMID33667722 Kochan N; Eskier D; Suner A; Karakulah G; Oktay Y Infect Genet Evol 2021[Jul]; 91 (ä): 104796 PMID33667722show ga SARS-CoV-2 is a betacoronavirus responsible for the COVID-19 pandemic that has affected millions of people worldwide. Pharmaceutical research against COVID-19 and the most frequently used tests for SARS-CoV-2 both depend on the genomic and peptide sequences of the virus for their robustness. Therefore, understanding the mutation rates and content of the virus is critical. Two key proteins for SARS-CoV-2 infection and replication are the S protein, responsible for viral entry into the cells, and RdRp, the RNA polymerase responsible for replicating the viral genome. Due to their roles in the viral cycle, these proteins are crucial for the fitness and infectiousness of the virus. Our previous findings had shown that the two most frequently observed mutations in the SARS-CoV-2 genome, 14408C>T in the RdRp coding region, and 23403A>G in the S gene, are correlated with higher mutation density over time. In this study, we further detail the selection dynamics and the mutation rates of SARS-CoV-2 genes, comparing them between isolates carrying both mutations, and isolates carrying neither. We find that the S gene and the RdRp coding region show the highest variance between the genotypes, and their selection dynamics contrast each other over time. The S gene displays higher tolerance for positive selection in mutant isolates early during the appearance of the double mutant genotype, and undergoes increasing negative selection over time, whereas the RdRp region in the mutant isolates shows strong negative selection throughout the pandemic. |*Genome, Viral[MESH] |*Point Mutation[MESH] |COVID-19/*epidemiology/transmission/virology[MESH] |Evolution, Molecular[MESH] |Gene Expression Regulation, Viral[MESH] |Genotype[MESH] |Humans[MESH] |Mutation Rate[MESH] |Open Reading Frames[MESH] |RNA-Dependent RNA Polymerase/*genetics[MESH] |SARS-CoV-2/classification/*genetics[MESH] |Selection, Genetic[MESH] |Spike Glycoprotein, Coronavirus/*genetics[MESH] |United Kingdom/epidemiology[MESH]Different selection dynamics of S and RdRp between SARS-CoV-2 genomes (epmc).pdf DeepDyve Pubget Overpricing