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10.1016/j.cmi.2021.02.020 http://scihub22266oqcxt.onion/10.1016/j.cmi.2021.02.020 33667629!7923873!33667629     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Microbiol+Infect 2021 ; 27 (6): 916.e1-916.e4 Nephropedia Template TP {{tp|p=33667629|t=2021. SARS CoV-2 infections in healthcare workers with a pre-existing T-cell response: a prospective cohort study |pdf=|usr=}}{{33667629}} gab.com Text SARS CoV-2 infections in healthcare workers with a pre-existing T-cell response: a prospective cohort study JO: Clin Microbiol Infect http://www.kidney.de/pget.php?&tw=1&pmid=33667629 #FOAvip OBJECTIVE: T-cell responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are observed in unexposed individuals. We evaluated the impact of this pre-existing cellular response on incident SARS-CoV-2 infections. METHODS: This was a follow-up study of 38 seronegative healthcare workers (HCWs) with previous evaluation of CD8+ and CD4+ T-cell responses after stimulation with SARS-CoV-2 structural proteins. Infection was considered in the presence of a positive RT-PCR test and/or confirmed seroconversion. RESULTS: Twenty of the 38 HCWs included (53%) had a previous specific CD8+ T-cell response to peptides encompassing the spike protein (S) in 13 (34%), the membrane (M) in 17 (45%), or/and the nucleocapsid (N) in three (8%). During a follow-up of 189 days (interquartile range (IQR) 172-195), 11 HCWs (29%) had an RT-PCR-positive test (n = 9) or seroconverted (n = 2). Median duration of symptoms was 2 days (IQR 0-7), and time to negative RT-PCR was 9 days (IQR 4-10). Notably, six incident infections (55%) occurred in HCWs with a pre-existing T-cell response (30% of those with a cellular response), who showed a significantly lower duration of symptoms (three were asymptomatic). Three of the six HCWs having a previous T-cell response continued to test seronegative. All the infected patients developed a robust T-cell response to different structural SARS-CoV-2 proteins, especially to protein S (91%). CONCLUSION: A pre-existing T-cell response does not seem to reduce incident SARS-CoV-2 infections, but it may contribute to asymptomatic or mild disease, rapid viral clearance and differences in seroconversion. Twit Text FOAVip SARS CoV-2 infections in healthcare workers with a pre-existing T-cell response: a prospective cohort study ????Clin Microbiol Infect http://www.kidney.de/pget.php?&tw=1&pmid=33667629 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33667629 #FOAvip English Wikipedia <ref>{{Cite pmid|33667629}}</ref> SARS CoV-2 infections in healthcare workers with a pre-existing T-cell response: a prospective cohort study #MMPMID33667629 Casado JL; Haemmerle J; Vizcarra P; Velasco H; Velasco T; Fernandez-Escribano M; Vallejo A Clin Microbiol Infect 2021[Jun]; 27 (6): 916.e1-916.e4 PMID33667629show ga OBJECTIVE: T-cell responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are observed in unexposed individuals. We evaluated the impact of this pre-existing cellular response on incident SARS-CoV-2 infections. METHODS: This was a follow-up study of 38 seronegative healthcare workers (HCWs) with previous evaluation of CD8+ and CD4+ T-cell responses after stimulation with SARS-CoV-2 structural proteins. Infection was considered in the presence of a positive RT-PCR test and/or confirmed seroconversion. RESULTS: Twenty of the 38 HCWs included (53%) had a previous specific CD8+ T-cell response to peptides encompassing the spike protein (S) in 13 (34%), the membrane (M) in 17 (45%), or/and the nucleocapsid (N) in three (8%). During a follow-up of 189 days (interquartile range (IQR) 172-195), 11 HCWs (29%) had an RT-PCR-positive test (n = 9) or seroconverted (n = 2). Median duration of symptoms was 2 days (IQR 0-7), and time to negative RT-PCR was 9 days (IQR 4-10). Notably, six incident infections (55%) occurred in HCWs with a pre-existing T-cell response (30% of those with a cellular response), who showed a significantly lower duration of symptoms (three were asymptomatic). Three of the six HCWs having a previous T-cell response continued to test seronegative. All the infected patients developed a robust T-cell response to different structural SARS-CoV-2 proteins, especially to protein S (91%). CONCLUSION: A pre-existing T-cell response does not seem to reduce incident SARS-CoV-2 infections, but it may contribute to asymptomatic or mild disease, rapid viral clearance and differences in seroconversion. |Adult[MESH] |Antibodies, Viral[MESH] |COVID-19 Nucleic Acid Testing[MESH] |COVID-19/*immunology[MESH] |Female[MESH] |Follow-Up Studies[MESH] |Health Personnel[MESH] |Humans[MESH] |Immunity[MESH] |Male[MESH] |Middle Aged[MESH] |Prospective Studies[MESH] |Seroconversion[MESH] |T-Lymphocytes/*immunology[MESH] |Viral Structural Proteins/*immunology[MESH]SARS CoV-2 infections in healthcare workers with a pre-existing T-cell(epmc).pdf DeepDyve Pubget Overpricing