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10.1016/j.ijbiomac.2021.02.203 http://scihub22266oqcxt.onion/10.1016/j.ijbiomac.2021.02.203 33667553!7921731!33667553     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33667553&cmd=llinks): Failed to open stream: HTTP request failed! 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The human pandemic coronaviruses on the show: The spike glycoprotein as the main actor in the coronaviruses play |pdf=|usr=}}{{33667553}} gab.com Text The human pandemic coronaviruses on the show: The spike glycoprotein as the main actor in the coronaviruses play JO: Int J Biol Macromol http://www.kidney.de/pget.php?&tw=1&pmid=33667553 #FOAvip Three coronaviruses (CoVs) have threatened the world population by causing outbreaks in the last two decades. In late 2019, the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged and caused the coronaviruses to disease 2019 (COVID-19), leading to the ongoing global outbreak. The other pandemic coronaviruses, SARS-CoV and Middle East respiratory syndrome CoV (MERS-CoV), share a considerable level of similarities at genomic and protein levels. However, the differences between them lead to distinct behaviors. These differences result from the accumulation of mutations in the sequence and structure of spike (S) glycoprotein, which plays an essential role in coronavirus infection, pathogenicity, transmission, and evolution. In this review, we brought together many studies narrating a sequence of events and highlighting the differences among S proteins from SARS-CoV, MERS-CoV, and SARS-CoV-2. It was performed here, analysis of S protein sequences and structures from the three pandemic coronaviruses pointing out the mutations among them and what they come through. Additionally, we investigated the receptor-binding domain (RBD) from all S proteins explaining the mutation and biological importance of all of them. Finally, we discuss the mutation in the S protein from several new isolates of SARS-CoV-2, reporting their difference and importance. This review brings into detail how the variations in S protein that make SARS-CoV-2 more aggressive than its relatives coronaviruses and other differences between coronaviruses. Twit Text FOAVip The human pandemic coronaviruses on the show: The spike glycoprotein as the main actor in the coronaviruses play ????Int J Biol Macromol http://www.kidney.de/pget.php?&tw=1&pmid=33667553 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33667553 #FOAvip English Wikipedia <ref>{{Cite pmid|33667553}}</ref> The human pandemic coronaviruses on the show: The spike glycoprotein as the main actor in the coronaviruses play #MMPMID33667553 Souza PFN; Mesquita FP; Amaral JL; Landim PGC; Lima KRP; Costa MB; Farias IR; Lima LB; Montenegro RC Int J Biol Macromol 2021[May]; 179 (ä): 1-19 PMID33667553show ga Three coronaviruses (CoVs) have threatened the world population by causing outbreaks in the last two decades. In late 2019, the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged and caused the coronaviruses to disease 2019 (COVID-19), leading to the ongoing global outbreak. The other pandemic coronaviruses, SARS-CoV and Middle East respiratory syndrome CoV (MERS-CoV), share a considerable level of similarities at genomic and protein levels. However, the differences between them lead to distinct behaviors. These differences result from the accumulation of mutations in the sequence and structure of spike (S) glycoprotein, which plays an essential role in coronavirus infection, pathogenicity, transmission, and evolution. In this review, we brought together many studies narrating a sequence of events and highlighting the differences among S proteins from SARS-CoV, MERS-CoV, and SARS-CoV-2. It was performed here, analysis of S protein sequences and structures from the three pandemic coronaviruses pointing out the mutations among them and what they come through. Additionally, we investigated the receptor-binding domain (RBD) from all S proteins explaining the mutation and biological importance of all of them. Finally, we discuss the mutation in the S protein from several new isolates of SARS-CoV-2, reporting their difference and importance. This review brings into detail how the variations in S protein that make SARS-CoV-2 more aggressive than its relatives coronaviruses and other differences between coronaviruses. |Animals[MESH] |COVID-19/epidemiology/metabolism/*virology[MESH] |Coronavirus Infections/epidemiology/metabolism/virology[MESH] |Humans[MESH] |Middle East Respiratory Syndrome Coronavirus/metabolism[MESH] |Pandemics[MESH] |Protein Binding[MESH] |SARS-CoV-2/*metabolism[MESH] |Severe acute respiratory syndrome-related coronavirus/metabolism[MESH]The human pandemic coronaviruses on the show: The spike glycoprotein a(epmc).pdf DeepDyve Pubget Overpricing