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10.1016/j.amjms.2021.03.001 http://scihub22266oqcxt.onion/10.1016/j.amjms.2021.03.001 33667433!7923853!33667433     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Med+Sci 2021 ; 361 (6): 725-730 Nephropedia Template TP {{tp|p=33667433|t=2021. Association of Pre-Admission Statin Use With Reduced In-Hospital Mortality in COVID-19 |pdf=|usr=}}{{33667433}} gab.com Text Association of Pre-Admission Statin Use With Reduced In-Hospital Mortality in COVID-19 JO: Am J Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=33667433 #FOAvip BACKGROUND: Coronavirus disease-19 (COVID-19) infection is associated with an uncontrolled systemic inflammatory response. Statins, given their anti-inflammatory properties, may reduce the associated morbidity and mortality. This study aimed to determine the association between statin use prior to hospitalization and in-hospital mortality in COVID-19 patients. METHODS: In this retrospective study, clinical data were collected from the electronic medical records of patients admitted to the hospital with confirmed COVID-19 infection from March 1, 2020 to April 24, 2020. A multivariate regression analysis was performed to study the association of pre-admission statin use with in-hospital mortality. RESULTS: Of 255 patients, 116 (45.5%) patients were on statins prior to admission and 139 (54.5%) were not. The statin group had a higher proportion of end stage renal disease (ESRD) (13.8% vs. 2.9%, p = 0.001), diabetes mellitus (63.8% vs. 35.2%, p<0.001), hypertension (87.9% vs. 61.1%, p < 0.001) and coronary artery disease (CAD) (33.6% vs. 5%, p < 0.001). On multivariate analysis, we found a statistically significant decrease in the odds of in-hospital mortality in patients on statins before admission (OR 0.14, 95% CI 0.03- 0.61, p = 0.008). In the subgroup analysis, statins were associated with a decrease in mortality in those with CAD (OR 0.02, 95% CI 0.0003-0.92 p = 0.045) and those without CAD (OR 0.05, 95% CI 0.005-0.43, p = 0.007). CONCLUSIONS: Our study suggests that statins are associated with reduced in-hospital mortality among patients with COVID-19, regardless of CAD status. More comprehensive epidemiological and molecular studies are needed to establish the role of statins in COVID-19. Twit Text FOAVip Association of Pre-Admission Statin Use With Reduced In-Hospital Mortality in COVID-19 ????Am J Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=33667433 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33667433 #FOAvip English Wikipedia <ref>{{Cite pmid|33667433}}</ref> Association of Pre-Admission Statin Use With Reduced In-Hospital Mortality in COVID-19 #MMPMID33667433 Chacko SR; DeJoy R 3rd; Lo KB; Albano J; Peterson E; Bhargav R; Gu F; Salacup G; Pelayo J; Azmaiparashvili Z; Rangaswami J; Patarroyo-Aponte G; Benzaquen S; Gupta E Am J Med Sci 2021[Jun]; 361 (6): 725-730 PMID33667433show ga BACKGROUND: Coronavirus disease-19 (COVID-19) infection is associated with an uncontrolled systemic inflammatory response. Statins, given their anti-inflammatory properties, may reduce the associated morbidity and mortality. This study aimed to determine the association between statin use prior to hospitalization and in-hospital mortality in COVID-19 patients. METHODS: In this retrospective study, clinical data were collected from the electronic medical records of patients admitted to the hospital with confirmed COVID-19 infection from March 1, 2020 to April 24, 2020. A multivariate regression analysis was performed to study the association of pre-admission statin use with in-hospital mortality. RESULTS: Of 255 patients, 116 (45.5%) patients were on statins prior to admission and 139 (54.5%) were not. The statin group had a higher proportion of end stage renal disease (ESRD) (13.8% vs. 2.9%, p = 0.001), diabetes mellitus (63.8% vs. 35.2%, p<0.001), hypertension (87.9% vs. 61.1%, p < 0.001) and coronary artery disease (CAD) (33.6% vs. 5%, p < 0.001). On multivariate analysis, we found a statistically significant decrease in the odds of in-hospital mortality in patients on statins before admission (OR 0.14, 95% CI 0.03- 0.61, p = 0.008). In the subgroup analysis, statins were associated with a decrease in mortality in those with CAD (OR 0.02, 95% CI 0.0003-0.92 p = 0.045) and those without CAD (OR 0.05, 95% CI 0.005-0.43, p = 0.007). CONCLUSIONS: Our study suggests that statins are associated with reduced in-hospital mortality among patients with COVID-19, regardless of CAD status. More comprehensive epidemiological and molecular studies are needed to establish the role of statins in COVID-19. |*COVID-19/mortality/therapy[MESH] |*Dyslipidemias/drug therapy/epidemiology[MESH] |*Hospital Mortality[MESH] |Aged[MESH] |Anti-Inflammatory Agents/therapeutic use[MESH] |Comorbidity[MESH] |Female[MESH] |Hospitalization/statistics & numerical data[MESH] |Humans[MESH] |Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use[MESH] |Male[MESH] |Mortality[MESH] |Outcome Assessment, Health Care[MESH] |Retrospective Studies[MESH] |Risk Factors[MESH] |SARS-CoV-2[MESH]Association of Pre-Admission Statin Use With Reduced In-Hospital Morta(epmc).pdf DeepDyve Pubget Overpricing