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10.1016/j.cell.2021.02.035 http://scihub22266oqcxt.onion/10.1016/j.cell.2021.02.035 33667349!7901298!33667349     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2021 ; 184 (7): 1821-1835.e16 Nephropedia Template TP {{tp|p=33667349|t=2021. Extremely potent human monoclonal antibodies from COVID-19 convalescent patients |pdf=|usr=}}{{33667349}} gab.com Text Extremely potent human monoclonal antibodies from COVID-19 convalescent patients JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=33667349 #FOAvip Human monoclonal antibodies are safe, preventive, and therapeutic tools that can be rapidly developed to help restore the massive health and economic disruption caused by the coronavirus disease 2019 (COVID-19) pandemic. By single-cell sorting 4,277 SARS-CoV-2 spike protein-specific memory B cells from 14 COVID-19 survivors, 453 neutralizing antibodies were identified. The most potent neutralizing antibodies recognized the spike protein receptor-binding domain, followed in potency by antibodies that recognize the S1 domain, the spike protein trimer, and the S2 subunit. Only 1.4% of them neutralized the authentic virus with a potency of 1-10 ng/mL. The most potent monoclonal antibody, engineered to reduce the risk of antibody-dependent enhancement and prolong half-life, neutralized the authentic wild-type virus and emerging variants containing D614G, E484K, and N501Y substitutions. Prophylactic and therapeutic efficacy in the hamster model was observed at 0.25 and 4 mg/kg respectively in absence of Fc functions. Twit Text FOAVip Extremely potent human monoclonal antibodies from COVID-19 convalescent patients ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=33667349 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33667349 #FOAvip English Wikipedia <ref>{{Cite pmid|33667349}}</ref> Extremely potent human monoclonal antibodies from COVID-19 convalescent patients #MMPMID33667349 Andreano E; Nicastri E; Paciello I; Pileri P; Manganaro N; Piccini G; Manenti A; Pantano E; Kabanova A; Troisi M; Vacca F; Cardamone D; De Santi C; Torres JL; Ozorowski G; Benincasa L; Jang H; Di Genova C; Depau L; Brunetti J; Agrati C; Capobianchi MR; Castilletti C; Emiliozzi A; Fabbiani M; Montagnani F; Bracci L; Sautto G; Ross TM; Montomoli E; Temperton N; Ward AB; Sala C; Ippolito G; Rappuoli R Cell 2021[Apr]; 184 (7): 1821-1835.e16 PMID33667349show ga Human monoclonal antibodies are safe, preventive, and therapeutic tools that can be rapidly developed to help restore the massive health and economic disruption caused by the coronavirus disease 2019 (COVID-19) pandemic. By single-cell sorting 4,277 SARS-CoV-2 spike protein-specific memory B cells from 14 COVID-19 survivors, 453 neutralizing antibodies were identified. The most potent neutralizing antibodies recognized the spike protein receptor-binding domain, followed in potency by antibodies that recognize the S1 domain, the spike protein trimer, and the S2 subunit. Only 1.4% of them neutralized the authentic virus with a potency of 1-10 ng/mL. The most potent monoclonal antibody, engineered to reduce the risk of antibody-dependent enhancement and prolong half-life, neutralized the authentic wild-type virus and emerging variants containing D614G, E484K, and N501Y substitutions. Prophylactic and therapeutic efficacy in the hamster model was observed at 0.25 and 4 mg/kg respectively in absence of Fc functions. |*COVID-19/immunology/prevention & control/therapy[MESH] |*Convalescence[MESH] |3T3 Cells[MESH] |Animals[MESH] |Antibodies, Monoclonal/*administration & dosage/isolation & purification[MESH] |Antibodies, Neutralizing/*administration & dosage/isolation & purification[MESH] |Antibodies, Viral/*administration & dosage/isolation & purification[MESH] |B-Lymphocytes/cytology/*immunology[MESH] |Chlorocebus aethiops[MESH] |Disease Models, Animal[MESH] |Female[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Immunoglobulin Fc Fragments/immunology[MESH] |Male[MESH] |Mice[MESH] |Spike Glycoprotein, Coronavirus/immunology[MESH]Extremely potent human monoclonal antibodies from COVID-19 convalescen(epmc).pdf DeepDyve Pubget Overpricing