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10.1111/trf.16339

http://scihub22266oqcxt.onion/10.1111/trf.16339
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suck abstract from ncbi


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pmid33665881      Transfusion 2021 ; 61 (4): 1064-1070
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  • ABO blood type association with SARS-CoV-2 infection mortality: A single-center population in New York City #MMPMID33665881
  • Szymanski J; Mohrmann L; Carter J; Nelson R; Chekuri S; Assa A; Spund B; Reyes-Gil M; Uehlinger J; Baron S; Paroder M
  • Transfusion 2021[Apr]; 61 (4): 1064-1070 PMID33665881show ga
  • BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a variable clinical course with significant mortality. Early reports suggested higher rates of SARS-CoV-2 infection in patients with type A blood and enrichment of type A individuals among COVID-19 mortalities. STUDY DESIGN AND METHODS: The study includes all patients hospitalized or with an emergency department (ED) visit who were tested for SARS-CoV-2 between March 10, 2020 and June 8, 2020 and had a positive test result by nucleic acid test (NAT) performed on a nasopharyngeal swab specimen. A total of 4968 patients met the study inclusion criteria, with a subsequent 23.1% (n = 1146/4968) all-cause mortality rate in the study cohort. To estimate overall risk by ABO type and account for the competing risks of in-hospital mortality and discharge, we calculated the cumulative incidence function (CIF) for each event. Cause-specific hazard ratios (csHRs) for in-hospital mortality and discharge were analyzed using multivariable Cox proportional hazards models. RESULTS: Type A blood was associated with the increased cause-specific hazard of death among COVID-19 patients compared to type O (HR = 1.17, 1.02-1.33, p = .02) and type B (HR = 1.32,1.10-1.58, p = .003). CONCLUSIONS: Our study shows that ABO histo-blood group type is associated with the risk of in-hospital death in COVID-19 patients, warranting additional inquiry. Elucidating the mechanism behind this association may reveal insights into the susceptibility and/or immunity to SARS-CoV-2.
  • |*Hospital Mortality[MESH]
  • |*Hospitals[MESH]
  • |ABO Blood-Group System[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19/*blood/*mortality/therapy[MESH]
  • |Disease-Free Survival[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Incidence[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |New York City/epidemiology[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2/*metabolism[MESH]


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