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10.1016/S2666-7568(20)30068-4 http://scihub22266oqcxt.onion/10.1016/S2666-7568(20)30068-4 33665645!7906698!33665645     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Lancet+Healthy+Longev 2021 ; 2 (2): e105-e111 Nephropedia Template TP {{tp|p=33665645|t=2021. The potential of rapalogs to enhance resilience against SARS-CoV-2 infection and reduce the severity of COVID-19 |pdf=|usr=}}{{33665645}} gab.com Text The potential of rapalogs to enhance resilience against SARS-CoV-2 infection and reduce the severity of COVID-19 JO: Lancet Healthy Longev http://www.kidney.de/pget.php?&tw=1&pmid=33665645 #FOAvip COVID-19 disproportionately affects older people, with likelihood of severe complications and death mirroring that of other age-associated diseases. Inhibition of the mechanistic target of rapamycin complex 1 (mTORC1) has been shown to delay or reverse many age-related phenotypes, including declining immune function. Rapamycin (sirolimus) and rapamycin derivatives are US Food and Drug Administration-approved inhibitors of mTORC1 with broad clinical utility and well established dosing and safety profiles. Based on preclinical and clinical evidence, a strong case can be made for immediate large-scale clinical trials to assess whether rapamycin and other mTORC1 inhibitors can prevent COVID-19 infection in these populations and also to determine whether these drugs can improve outcomes in patients with severe COVID-19. Twit Text FOAVip The potential of rapalogs to enhance resilience against SARS-CoV-2 infection and reduce the severity of COVID-19 ????Lancet Healthy Longev http://www.kidney.de/pget.php?&tw=1&pmid=33665645 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33665645 #FOAvip English Wikipedia <ref>{{Cite pmid|33665645}}</ref> The potential of rapalogs to enhance resilience against SARS-CoV-2 infection and reduce the severity of COVID-19 #MMPMID33665645 Bischof E; Siow RC; Zhavoronkov A; Kaeberlein M Lancet Healthy Longev 2021[Feb]; 2 (2): e105-e111 PMID33665645show ga COVID-19 disproportionately affects older people, with likelihood of severe complications and death mirroring that of other age-associated diseases. Inhibition of the mechanistic target of rapamycin complex 1 (mTORC1) has been shown to delay or reverse many age-related phenotypes, including declining immune function. Rapamycin (sirolimus) and rapamycin derivatives are US Food and Drug Administration-approved inhibitors of mTORC1 with broad clinical utility and well established dosing and safety profiles. Based on preclinical and clinical evidence, a strong case can be made for immediate large-scale clinical trials to assess whether rapamycin and other mTORC1 inhibitors can prevent COVID-19 infection in these populations and also to determine whether these drugs can improve outcomes in patients with severe COVID-19. |*COVID-19[MESH] |Humans[MESH] |MTOR Inhibitors[MESH] |Mechanistic Target of Rapamycin Complex 1[MESH] |SARS-CoV-2[MESH] |Sirolimus[MESH]The potential of rapalogs to enhance resilience against SARS-CoV-2 inf(epmc).pdf DeepDyve Pubget Overpricing