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10.1126/sciimmunol.abg6461

http://scihub22266oqcxt.onion/10.1126/sciimmunol.abg6461
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33664060!8224398!33664060
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suck abstract from ncbi


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pmid33664060      Sci+Immunol 2021 ; 6 (57): ä
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  • SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8(+) T cell responses #MMPMID33664060
  • Agerer B; Koblischke M; Gudipati V; Montano-Gutierrez LF; Smyth M; Popa A; Genger JW; Endler L; Florian DM; Muhlgrabner V; Graninger M; Aberle SW; Husa AM; Shaw LE; Lercher A; Gattinger P; Torralba-Gombau R; Trapin D; Penz T; Barreca D; Fae I; Wenda S; Traugott M; Walder G; Pickl WF; Thiel V; Allerberger F; Stockinger H; Puchhammer-Stockl E; Weninger W; Fischer G; Hoepler W; Pawelka E; Zoufaly A; Valenta R; Bock C; Paster W; Geyeregger R; Farlik M; Halbritter F; Huppa JB; Aberle JH; Bergthaler A
  • Sci Immunol 2021[Mar]; 6 (57): ä PMID33664060show ga
  • CD8(+) T cell immunity to SARS-CoV-2 has been implicated in COVID-19 severity and virus control. Here, we identified nonsynonymous mutations in MHC-I-restricted CD8(+) T cell epitopes after deep sequencing of 747 SARS-CoV-2 virus isolates. Mutant peptides exhibited diminished or abrogated MHC-I binding in a cell-free in vitro assay. Reduced MHC-I binding of mutant peptides was associated with decreased proliferation, IFN-gamma production and cytotoxic activity of CD8(+) T cells isolated from HLA-matched COVID-19 patients. Single cell RNA sequencing of ex vivo expanded, tetramer-sorted CD8(+) T cells from COVID-19 patients further revealed qualitative differences in the transcriptional response to mutant peptides. Our findings highlight the capacity of SARS-CoV-2 to subvert CD8(+) T cell surveillance through point mutations in MHC-I-restricted viral epitopes.
  • |*COVID-19/genetics/immunology/pathology[MESH]
  • |*Epitopes, T-Lymphocyte/genetics/immunology[MESH]
  • |*Immunity, Cellular[MESH]
  • |*Mutation[MESH]
  • |*SARS-CoV-2/genetics/immunology[MESH]
  • |CD8-Positive T-Lymphocytes/*immunology/pathology[MESH]
  • |Cell Proliferation[MESH]
  • |HLA-A Antigens/*immunology[MESH]
  • |High-Throughput Nucleotide Sequencing[MESH]
  • |Humans[MESH]
  • |Interferon-gamma/immunology[MESH]


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