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10.1126/sciimmunol.abg6461 http://scihub22266oqcxt.onion/10.1126/sciimmunol.abg6461 33664060!8224398!33664060     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33664060.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Immunol 2021 ; 6 (57): ä Nephropedia Template TP {{tp|p=33664060|t=2021. SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8(+) T cell responses |pdf=|usr=}}{{33664060}} gab.com Text SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8(+) T cell responses JO: Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33664060 #FOAvip CD8(+) T cell immunity to SARS-CoV-2 has been implicated in COVID-19 severity and virus control. Here, we identified nonsynonymous mutations in MHC-I-restricted CD8(+) T cell epitopes after deep sequencing of 747 SARS-CoV-2 virus isolates. Mutant peptides exhibited diminished or abrogated MHC-I binding in a cell-free in vitro assay. Reduced MHC-I binding of mutant peptides was associated with decreased proliferation, IFN-gamma production and cytotoxic activity of CD8(+) T cells isolated from HLA-matched COVID-19 patients. Single cell RNA sequencing of ex vivo expanded, tetramer-sorted CD8(+) T cells from COVID-19 patients further revealed qualitative differences in the transcriptional response to mutant peptides. Our findings highlight the capacity of SARS-CoV-2 to subvert CD8(+) T cell surveillance through point mutations in MHC-I-restricted viral epitopes. Twit Text FOAVip SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8(+) T cell responses ????Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33664060 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33664060 #FOAvip English Wikipedia <ref>{{Cite pmid|33664060}}</ref> SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8(+) T cell responses #MMPMID33664060 Agerer B; Koblischke M; Gudipati V; Montano-Gutierrez LF; Smyth M; Popa A; Genger JW; Endler L; Florian DM; Muhlgrabner V; Graninger M; Aberle SW; Husa AM; Shaw LE; Lercher A; Gattinger P; Torralba-Gombau R; Trapin D; Penz T; Barreca D; Fae I; Wenda S; Traugott M; Walder G; Pickl WF; Thiel V; Allerberger F; Stockinger H; Puchhammer-Stockl E; Weninger W; Fischer G; Hoepler W; Pawelka E; Zoufaly A; Valenta R; Bock C; Paster W; Geyeregger R; Farlik M; Halbritter F; Huppa JB; Aberle JH; Bergthaler A Sci Immunol 2021[Mar]; 6 (57): ä PMID33664060show ga CD8(+) T cell immunity to SARS-CoV-2 has been implicated in COVID-19 severity and virus control. Here, we identified nonsynonymous mutations in MHC-I-restricted CD8(+) T cell epitopes after deep sequencing of 747 SARS-CoV-2 virus isolates. Mutant peptides exhibited diminished or abrogated MHC-I binding in a cell-free in vitro assay. Reduced MHC-I binding of mutant peptides was associated with decreased proliferation, IFN-gamma production and cytotoxic activity of CD8(+) T cells isolated from HLA-matched COVID-19 patients. Single cell RNA sequencing of ex vivo expanded, tetramer-sorted CD8(+) T cells from COVID-19 patients further revealed qualitative differences in the transcriptional response to mutant peptides. Our findings highlight the capacity of SARS-CoV-2 to subvert CD8(+) T cell surveillance through point mutations in MHC-I-restricted viral epitopes. |*COVID-19/genetics/immunology/pathology[MESH] |*Epitopes, T-Lymphocyte/genetics/immunology[MESH] |*Immunity, Cellular[MESH] |*Mutation[MESH] |*SARS-CoV-2/genetics/immunology[MESH] |CD8-Positive T-Lymphocytes/*immunology/pathology[MESH] |Cell Proliferation[MESH] |HLA-A Antigens/*immunology[MESH] |High-Throughput Nucleotide Sequencing[MESH] |Humans[MESH] |Interferon-gamma/immunology[MESH]SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8(+) T cell (epmc).pdf DeepDyve Pubget Overpricing