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10.1016/j.nano.2021.102372 http://scihub22266oqcxt.onion/10.1016/j.nano.2021.102372 33662593!7920803!33662593     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nanomedicine 2021 ; 34 (ä): 102372 Nephropedia Template TP {{tp|p=33662593|t=2021. Synthesis and immunogenicity assessment of a gold nanoparticle conjugate for the delivery of a peptide from SARS-CoV-2 |pdf=|usr=}}{{33662593}} gab.com Text Synthesis and immunogenicity assessment of a gold nanoparticle conjugate for the delivery of a peptide from SARS-CoV-2 JO: Nanomedicine http://www.kidney.de/pget.php?&tw=1&pmid=33662593 #FOAvip The development of vaccines is a crucial response against the COVID-19 pandemic and innovative nanovaccines could increase the potential to address this remarkable challenge. In the present study a B cell epitope (S(461-493)) from the spike protein of SARS-CoV-2 was selected and its immunogenicity validated in sheep. This synthetic peptide was coupled to gold nanoparticles (AuNP) functionalized with SH-PEG-NH(2) via glutaraldehyde-mediated coupling to obtain the AuNP-S(461-493) candidate, which showed in s.c.-immunized mice a superior immunogenicity (IgG responses) when compared to soluble S(461-493); and led to increased expression of relevant cytokines in splenocyte cultures. Interestingly, the response triggered by AuNP-S(461-493) was similar in magnitude to that induced using a conventional strong adjuvant (Freund's adjuvant). This study provides a platform for the development of AuNP-based nanovaccines targeting specific SARS-CoV-2 epitopes. Twit Text FOAVip Synthesis and immunogenicity assessment of a gold nanoparticle conjugate for the delivery of a peptide from SARS-CoV-2 ????Nanomedicine http://www.kidney.de/pget.php?&tw=1&pmid=33662593 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33662593 #FOAvip English Wikipedia <ref>{{Cite pmid|33662593}}</ref> Synthesis and immunogenicity assessment of a gold nanoparticle conjugate for the delivery of a peptide from SARS-CoV-2 #MMPMID33662593 Farfan-Castro S; Garcia-Soto MJ; Comas-Garcia M; Arevalo-Villalobos JI; Palestino G; Gonzalez-Ortega O; Rosales-Mendoza S Nanomedicine 2021[Jun]; 34 (ä): 102372 PMID33662593show ga The development of vaccines is a crucial response against the COVID-19 pandemic and innovative nanovaccines could increase the potential to address this remarkable challenge. In the present study a B cell epitope (S(461-493)) from the spike protein of SARS-CoV-2 was selected and its immunogenicity validated in sheep. This synthetic peptide was coupled to gold nanoparticles (AuNP) functionalized with SH-PEG-NH(2) via glutaraldehyde-mediated coupling to obtain the AuNP-S(461-493) candidate, which showed in s.c.-immunized mice a superior immunogenicity (IgG responses) when compared to soluble S(461-493); and led to increased expression of relevant cytokines in splenocyte cultures. Interestingly, the response triggered by AuNP-S(461-493) was similar in magnitude to that induced using a conventional strong adjuvant (Freund's adjuvant). This study provides a platform for the development of AuNP-based nanovaccines targeting specific SARS-CoV-2 epitopes. |*COVID-19 Vaccines/chemical synthesis/chemistry/immunology/pharmacology[MESH] |*Epitopes, B-Lymphocyte/chemistry/immunology/pharmacology[MESH] |*Gold/chemistry/pharmacology[MESH] |*Immunogenicity, Vaccine[MESH] |*Metal Nanoparticles/chemistry/therapeutic use[MESH] |*Peptides/chemical synthesis/chemistry/immunology/pharmacology[MESH] |*Spike Glycoprotein, Coronavirus/chemistry/immunology/pharmacology[MESH] |Animals[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH]Synthesis and immunogenicity assessment of a gold nanoparticle conjuga(epmc).pdf DeepDyve Pubget Overpricing