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10.1016/j.bmcl.2021.127885 http://scihub22266oqcxt.onion/10.1016/j.bmcl.2021.127885 33662537!7920804!33662537     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33662537&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Bioorg+Med+Chem+Lett 2021 ; 39 (ä): 127885 Nephropedia Template TP {{tp|p=33662537|t=2021. Design, synthesis and biological evaluation of 2-aminoquinazolin-4(3H)-one derivatives as potential SARS-CoV-2 and MERS-CoV treatments |pdf=|usr=}}{{33662537}} gab.com Text Design, synthesis and biological evaluation of 2-aminoquinazolin-4(3H)-one derivatives as potential SARS-CoV-2 and MERS-CoV treatments JO: Bioorg Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=33662537 #FOAvip Despite the rising threat of fatal coronaviruses, there are no general proven effective antivirals to treat them. 2-Aminoquinazolin-4(3H)-one derivatives were newly designed, synthesized, and investigated to show the inhibitory effects on SARS-CoV-2 and MERS-CoV. Among the synthesized derivatives, 7-chloro-2-((3,5-dichlorophenyl)amino)quinazolin-4(3H)-one (9g) and 2-((3,5-dichlorophenyl)amino)-5-hydroxyquinazolin-4 (3H)-one (11e) showed the most potent anti-SARS-CoV-2 activities (IC(50) < 0.25 muM) and anti-MERS-CoV activities (IC(50) < 1.1 muM) with no cytotoxicity (CC(50) > 25 muM). In addition, both compounds showed acceptable results in metabolic stabilities, hERG binding affinities, CYP inhibitions, and preliminary PK studies. Twit Text FOAVip Design, synthesis and biological evaluation of 2-aminoquinazolin-4(3H)-one derivatives as potential SARS-CoV-2 and MERS-CoV treatments ????Bioorg Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=33662537 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33662537 #FOAvip English Wikipedia <ref>{{Cite pmid|33662537}}</ref> Design, synthesis and biological evaluation of 2-aminoquinazolin-4(3H)-one derivatives as potential SARS-CoV-2 and MERS-CoV treatments #MMPMID33662537 Lee JY; Shin YS; Jeon S; Lee SI; Noh S; Cho JE; Jang MS; Kim S; Song JH; Kim HR; Park CM Bioorg Med Chem Lett 2021[May]; 39 (ä): 127885 PMID33662537show ga Despite the rising threat of fatal coronaviruses, there are no general proven effective antivirals to treat them. 2-Aminoquinazolin-4(3H)-one derivatives were newly designed, synthesized, and investigated to show the inhibitory effects on SARS-CoV-2 and MERS-CoV. Among the synthesized derivatives, 7-chloro-2-((3,5-dichlorophenyl)amino)quinazolin-4(3H)-one (9g) and 2-((3,5-dichlorophenyl)amino)-5-hydroxyquinazolin-4 (3H)-one (11e) showed the most potent anti-SARS-CoV-2 activities (IC(50) < 0.25 muM) and anti-MERS-CoV activities (IC(50) < 1.1 muM) with no cytotoxicity (CC(50) > 25 muM). In addition, both compounds showed acceptable results in metabolic stabilities, hERG binding affinities, CYP inhibitions, and preliminary PK studies. |*Drug Design[MESH] |Animals[MESH] |Antiviral Agents/*chemical synthesis/pharmacokinetics/pharmacology/therapeutic use[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/virology[MESH] |Cell Line[MESH] |Cell Survival/drug effects[MESH] |Coronavirus Infections/drug therapy/virology[MESH] |Cytochrome P-450 Enzyme System/chemistry/metabolism[MESH] |Half-Life[MESH] |Humans[MESH] |Inhibitory Concentration 50[MESH] |Mice[MESH] |Microsomes/metabolism[MESH] |Middle East Respiratory Syndrome Coronavirus/*drug effects/isolation & purification[MESH] |Quinazolinones/chemistry/metabolism/*pharmacology/therapeutic use[MESH] |Rats[MESH] |SARS-CoV-2/*drug effects/isolation & purification[MESH]Design, synthesis and biological evaluation of 2-aminoquinazolin-4(3H)(epmc).pdf DeepDyve Pubget Overpricing