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10.1016/j.metabol.2021.154739 http://scihub22266oqcxt.onion/10.1016/j.metabol.2021.154739 33662365!7920809!33662365     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Metabolism 2021 ; 118 (ä): 154739 Nephropedia Template TP {{tp|p=33662365|t=2021. The serum metabolome of COVID-19 patients is distinctive and predictive |pdf=|usr=}}{{33662365}} gab.com Text The serum metabolome of COVID-19 patients is distinctive and predictive JO: Metabolism http://www.kidney.de/pget.php?&tw=1&pmid=33662365 #FOAvip BACKGROUND: Metabolism is critical for sustaining life, immunity and infection, but its role in COVID-19 is not fully understood. METHODS: Seventy-nine COVID-19 patients, 78 healthy controls (HCs) and 30 COVID-19-like patients were recruited in a prospective cohort study. Samples were collected from COVID-19 patients with mild or severe symptoms on admission, patients who progressed from mild to severe symptoms, and patients who were followed from hospital admission to discharge. The metabolome was assayed using gas chromatography-mass spectrometry. RESULTS: Serum butyric acid, 2-hydroxybutyric acid, l-glutamic acid, l-phenylalanine, l-serine, l-lactic acid, and cholesterol were enriched in COVID-19 and COVID-19-like patients versus HCs. Notably, d-fructose and succinic acid were enriched, and citric acid and 2-palmitoyl-glycerol were depleted in COVID-19 patients compared to COVID-19-like patients and HCs, and these four metabolites were not differentially distributed in non-COVID-19 groups. COVID-19 patients had enriched 4-deoxythreonic acid and depleted 1,5-anhydroglucitol compared to HCs and enriched oxalic acid and depleted phosphoric acid compared to COVID-19-like patients. A combination of d-fructose, citric acid and 2-palmitoyl-glycerol distinguished COVID-19 patients from HCs and COVID-19-like patients, with an area under the curve (AUC)?>?0.92 after validation. The combination of 2-hydroxy-3-methylbutyric acid, 3-hydroxybutyric acid, cholesterol, succinic acid, L-ornithine, oleic acid and palmitelaidic acid predicted patients who progressed from mild to severe COVID-19, with an AUC of 0.969. After discharge, nearly one-third of metabolites were recovered in COVID-19 patients. CONCLUSIONS: The serum metabolome of COVID-19 patients is distinctive and has important value in investigating pathogenesis, determining a diagnosis, predicting severe cases, and improving treatment. Twit Text FOAVip The serum metabolome of COVID-19 patients is distinctive and predictive ????Metabolism http://www.kidney.de/pget.php?&tw=1&pmid=33662365 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33662365 #FOAvip English Wikipedia <ref>{{Cite pmid|33662365}}</ref> The serum metabolome of COVID-19 patients is distinctive and predictive #MMPMID33662365 Shi D; Yan R; Lv L; Jiang H; Lu Y; Sheng J; Xie J; Wu W; Xia J; Xu K; Gu S; Chen Y; Huang C; Guo J; Du Y; Li L Metabolism 2021[May]; 118 (ä): 154739 PMID33662365show ga BACKGROUND: Metabolism is critical for sustaining life, immunity and infection, but its role in COVID-19 is not fully understood. METHODS: Seventy-nine COVID-19 patients, 78 healthy controls (HCs) and 30 COVID-19-like patients were recruited in a prospective cohort study. Samples were collected from COVID-19 patients with mild or severe symptoms on admission, patients who progressed from mild to severe symptoms, and patients who were followed from hospital admission to discharge. The metabolome was assayed using gas chromatography-mass spectrometry. RESULTS: Serum butyric acid, 2-hydroxybutyric acid, l-glutamic acid, l-phenylalanine, l-serine, l-lactic acid, and cholesterol were enriched in COVID-19 and COVID-19-like patients versus HCs. Notably, d-fructose and succinic acid were enriched, and citric acid and 2-palmitoyl-glycerol were depleted in COVID-19 patients compared to COVID-19-like patients and HCs, and these four metabolites were not differentially distributed in non-COVID-19 groups. COVID-19 patients had enriched 4-deoxythreonic acid and depleted 1,5-anhydroglucitol compared to HCs and enriched oxalic acid and depleted phosphoric acid compared to COVID-19-like patients. A combination of d-fructose, citric acid and 2-palmitoyl-glycerol distinguished COVID-19 patients from HCs and COVID-19-like patients, with an area under the curve (AUC)?>?0.92 after validation. The combination of 2-hydroxy-3-methylbutyric acid, 3-hydroxybutyric acid, cholesterol, succinic acid, L-ornithine, oleic acid and palmitelaidic acid predicted patients who progressed from mild to severe COVID-19, with an AUC of 0.969. After discharge, nearly one-third of metabolites were recovered in COVID-19 patients. CONCLUSIONS: The serum metabolome of COVID-19 patients is distinctive and has important value in investigating pathogenesis, determining a diagnosis, predicting severe cases, and improving treatment. |*Metabolome[MESH] |*SARS-CoV-2[MESH] |Adult[MESH] |Aged[MESH] |Amino Acids/blood[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/*metabolism[MESH] |Cholesterol/blood[MESH] |Female[MESH] |Fructose/blood[MESH] |Gas Chromatography-Mass Spectrometry[MESH] |Humans[MESH] |Hydroxybutyrates/blood[MESH] |Lactic Acid/blood[MESH] |Male[MESH] |Middle Aged[MESH]The serum metabolome of COVID-19 patients is distinctive and predictiv(epmc).pdf DeepDyve Pubget Overpricing