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10.1371/journal.pone.0247799 http://scihub22266oqcxt.onion/10.1371/journal.pone.0247799 33662015!7932534!33662015     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2021 ; 16 (3): e0247799 Nephropedia Template TP {{tp|p=33662015|t=2021. Genomic characterization and evolution of SARS-CoV-2 of a Canadian population |pdf=|usr=}}{{33662015}} gab.com Text Genomic characterization and evolution of SARS-CoV-2 of a Canadian population JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=33662015 #FOAvip COVID-19 has greatly affected public health and world economy. In this study, we analyzed 129 full-length genomes of SARS-CoV-2 viruses of a Canadian population during early phase of the pandemic. Phylogenetic analysis revealed three major paths of transmission of SARS-CoV-2 viruses into Canada. Twenty-one substitutions that have frequencies greater than 3% of viral population were identified. Analysis of these substitutions indicated that P1427I (ORF1b), Y1464C (ORF1b), and Q57H (ORF3a) might affect functions of the corresponding SARS-CoV-2 encoded proteins. Additionally, we found the evidence of positive selection on the ORF3a and codon 614 of Spike protein, suggesting the viral components responsible for host entry and activation of inflammation response were targeted by host immune responses. The study showed genomic variation and evolution of SARS-CoV-2 in a Canadian population. These information may help develop preventive strategies and be used for further study of SARS-CoV-2 pathogenesis and therapeutics development. Twit Text FOAVip Genomic characterization and evolution of SARS-CoV-2 of a Canadian population ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=33662015 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33662015 #FOAvip English Wikipedia <ref>{{Cite pmid|33662015}}</ref> Genomic characterization and evolution of SARS-CoV-2 of a Canadian population #MMPMID33662015 Zhang M; Li L; Luo M; Liang B PLoS One 2021[]; 16 (3): e0247799 PMID33662015show ga COVID-19 has greatly affected public health and world economy. In this study, we analyzed 129 full-length genomes of SARS-CoV-2 viruses of a Canadian population during early phase of the pandemic. Phylogenetic analysis revealed three major paths of transmission of SARS-CoV-2 viruses into Canada. Twenty-one substitutions that have frequencies greater than 3% of viral population were identified. Analysis of these substitutions indicated that P1427I (ORF1b), Y1464C (ORF1b), and Q57H (ORF3a) might affect functions of the corresponding SARS-CoV-2 encoded proteins. Additionally, we found the evidence of positive selection on the ORF3a and codon 614 of Spike protein, suggesting the viral components responsible for host entry and activation of inflammation response were targeted by host immune responses. The study showed genomic variation and evolution of SARS-CoV-2 in a Canadian population. These information may help develop preventive strategies and be used for further study of SARS-CoV-2 pathogenesis and therapeutics development. |*Genome, Viral[MESH] |COVID-19/epidemiology/*virology[MESH] |Canada/epidemiology[MESH] |Evolution, Molecular[MESH] |Genetic Variation[MESH] |Humans[MESH] |Phylogeny[MESH] |SARS-CoV-2/*genetics/isolation & purification[MESH] |Spike Glycoprotein, Coronavirus/genetics[MESH]Genomic characterization and evolution of SARS-CoV-2 of a Canadian pop(epmc).pdf DeepDyve Pubget Overpricing