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10.1007/BF00542490

http://scihub22266oqcxt.onion/10.1007/BF00542490
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3366161!ä!3366161

suck abstract from ncbi


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pmid3366161      Eur+J+Clin+Pharmacol 1988 ; 33 (6): 577-9
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  • Effects of triamterene on serum and skeletal muscle electrolytes in diuretic-treated patients #MMPMID3366161
  • Widmann L; Dyckner T; Wester PO
  • Eur J Clin Pharmacol 1988[]; 33 (6): 577-9 PMID3366161show ga
  • The effects on plasma and skeletal muscle electrolytes of the combination of triamterene 37.5 mg and hydrochlorothiazide 25 mg daily were studied in 19 patients on prior long-term (greater than 1 year) diuretic therapy for arterial hypertension and/or congestive heart failure. A further 20 patients fulfilling the same admission criteria were used as controls. Blood samples and skeletal muscle biopsies were taken before the study and after 6 months on therapy. The diuretic-treated group had a significant increase in skeletal muscle potassium and magnesium after 6 months on therapy as compared to the controls. Thus, the combination of triamterene and hydrochlorothiazide appeared effective in preserving the cellular content of potassium and magnesium on a long-term basis in the type of patient studied.
  • |Aged[MESH]
  • |Blood Pressure/drug effects[MESH]
  • |Body Water/metabolism[MESH]
  • |Diuretics/administration & dosage/*therapeutic use[MESH]
  • |Drug Therapy, Combination[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Magnesium/blood/*metabolism[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Muscles/*metabolism[MESH]
  • |Potassium/blood/*metabolism[MESH]
  • |Triamterene/administration & dosage/*pharmacology[MESH]


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