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10.1080/21505594.2021.1871823 http://scihub22266oqcxt.onion/10.1080/21505594.2021.1871823 33660566!7939569!33660566     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Virulence 2021 ; 12 (1): 444-469 Nephropedia Template TP {{tp|p=33660566|t=2021. Host Defence RNases as Antiviral Agents against Enveloped Single Stranded RNA Viruses |pdf=|usr=}}{{33660566}} gab.com Text Host Defence RNases as Antiviral Agents against Enveloped Single Stranded RNA Viruses JO: Virulence http://www.kidney.de/pget.php?&tw=1&pmid=33660566 #FOAvip Owing to the recent outbreak of Coronavirus Disease of 2019 (COVID-19), it is urgent to develop effective and safe drugs to treat the present pandemic and prevent other viral infections that might come in the future. Proteins from our own innate immune system can serve as ideal sources of novel drug candidates thanks to their safety and immune regulation versatility. Some host defense RNases equipped with antiviral activity have been reported over time. Here, we try to summarize the currently available information on human RNases that can target viral pathogens, with special focus on enveloped single-stranded RNA (ssRNA) viruses. Overall, host RNases can fight viruses by a combined multifaceted strategy, including the enzymatic target of the viral genome, recognition of virus unique patterns, immune modulation, control of stress granule formation, and induction of autophagy/apoptosis pathways. The review also includes a detailed description of representative enveloped ssRNA viruses and their strategies to interact with the host and evade immune recognition. For comparative purposes, we also provide an exhaustive revision of the currently approved or experimental antiviral drugs. Finally, we sum up the current perspectives of drug development to achieve successful eradication of viral infections. Twit Text FOAVip Host Defence RNases as Antiviral Agents against Enveloped Single Stranded RNA Viruses ????Virulence http://www.kidney.de/pget.php?&tw=1&pmid=33660566 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33660566 #FOAvip English Wikipedia <ref>{{Cite pmid|33660566}}</ref> Host Defence RNases as Antiviral Agents against Enveloped Single Stranded RNA Viruses #MMPMID33660566 Li J; Boix E Virulence 2021[Dec]; 12 (1): 444-469 PMID33660566show ga Owing to the recent outbreak of Coronavirus Disease of 2019 (COVID-19), it is urgent to develop effective and safe drugs to treat the present pandemic and prevent other viral infections that might come in the future. Proteins from our own innate immune system can serve as ideal sources of novel drug candidates thanks to their safety and immune regulation versatility. Some host defense RNases equipped with antiviral activity have been reported over time. Here, we try to summarize the currently available information on human RNases that can target viral pathogens, with special focus on enveloped single-stranded RNA (ssRNA) viruses. Overall, host RNases can fight viruses by a combined multifaceted strategy, including the enzymatic target of the viral genome, recognition of virus unique patterns, immune modulation, control of stress granule formation, and induction of autophagy/apoptosis pathways. The review also includes a detailed description of representative enveloped ssRNA viruses and their strategies to interact with the host and evade immune recognition. For comparative purposes, we also provide an exhaustive revision of the currently approved or experimental antiviral drugs. Finally, we sum up the current perspectives of drug development to achieve successful eradication of viral infections. |*COVID-19 Drug Treatment[MESH] |Endoribonucleases/*metabolism[MESH] |Eosinophils/metabolism[MESH] |Humans[MESH] |Pathogen-Associated Molecular Pattern Molecules/metabolism[MESH] |RNA, Viral/*metabolism[MESH] |Ribonuclease, Pancreatic/*metabolism[MESH] |SARS-CoV-2/drug effects/immunology[MESH]Host Defence RNases as Antiviral Agents against Enveloped Single Stran(epmc).pdf DeepDyve Pubget Overpricing