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10.1007/s11095-021-03015-x http://scihub22266oqcxt.onion/10.1007/s11095-021-03015-x 33660201!7928182!33660201     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pharm+Res 2021 ; 38 (3): 473-478 Nephropedia Template TP {{tp|p=33660201|t=2021. Nanoparticle-Mediated Cytoplasmic Delivery of Messenger RNA Vaccines: Challenges and Future Perspectives |pdf=|usr=}}{{33660201}} gab.com Text Nanoparticle-Mediated Cytoplasmic Delivery of Messenger RNA Vaccines: Challenges and Future Perspectives JO: Pharm Res http://www.kidney.de/pget.php?&tw=1&pmid=33660201 #FOAvip The COVID-19 pandemic has left scientists and clinicians no choice but a race to find solutions to save lives while controlling the rapid spreading. Messenger RNA (mRNA)-based vaccines have become the front-runners because of their safety profiles, precise and reproducible immune response with more cost-effective and faster production than other types of vaccines. However, the physicochemical properties of naked mRNA necessitate innovative delivery technologies to ferry these 'messengers' to ribosomes inside cells by crossing various barriers and subsequently induce an immune response. Intracellular delivery followed by endosomal escape represents the key strategies for cytoplasmic delivery of mRNA vaccines to the target. This Perspective provides insights into how state-of-the-art nanotechnology helps break the delivery barriers and advance the development of mRNA vaccines. The challenges remaining and future perspectives are outlined. Twit Text FOAVip Nanoparticle-Mediated Cytoplasmic Delivery of Messenger RNA Vaccines: Challenges and Future Perspectives ????Pharm Res http://www.kidney.de/pget.php?&tw=1&pmid=33660201 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33660201 #FOAvip English Wikipedia <ref>{{Cite pmid|33660201}}</ref> Nanoparticle-Mediated Cytoplasmic Delivery of Messenger RNA Vaccines: Challenges and Future Perspectives #MMPMID33660201 Wu Z; Li T Pharm Res 2021[Mar]; 38 (3): 473-478 PMID33660201show ga The COVID-19 pandemic has left scientists and clinicians no choice but a race to find solutions to save lives while controlling the rapid spreading. Messenger RNA (mRNA)-based vaccines have become the front-runners because of their safety profiles, precise and reproducible immune response with more cost-effective and faster production than other types of vaccines. However, the physicochemical properties of naked mRNA necessitate innovative delivery technologies to ferry these 'messengers' to ribosomes inside cells by crossing various barriers and subsequently induce an immune response. Intracellular delivery followed by endosomal escape represents the key strategies for cytoplasmic delivery of mRNA vaccines to the target. This Perspective provides insights into how state-of-the-art nanotechnology helps break the delivery barriers and advance the development of mRNA vaccines. The challenges remaining and future perspectives are outlined. |*Drug Carriers[MESH] |*Nanoparticles[MESH] |2019-nCoV Vaccine mRNA-1273[MESH] |Animals[MESH] |BNT162 Vaccine[MESH] |COVID-19 Vaccines/chemistry/pharmacokinetics/*therapeutic use[MESH] |COVID-19/immunology/*prevention & control/virology[MESH] |Cytoplasm/*metabolism[MESH] |Drug Compounding[MESH] |Humans[MESH] |Lipids/*chemistry[MESH] |Nanomedicine[MESH] |Ribosomes/*metabolism[MESH] |Vaccines, Synthetic/chemistry/*therapeutic use[MESH]Nanoparticle-Mediated Cytoplasmic Delivery of Messenger RNA Vaccines: (epmc).pdf DeepDyve Pubget Overpricing