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10.3389/fmed.2021.585358

http://scihub22266oqcxt.onion/10.3389/fmed.2021.585358
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33659260!7917136!33659260
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suck abstract from ncbi


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pmid33659260      Front+Med+(Lausanne) 2021 ; 8 (ä): 585358
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  • Population Bottlenecks and Intra-host Evolution During Human-to-Human Transmission of SARS-CoV-2 #MMPMID33659260
  • Wang D; Wang Y; Sun W; Zhang L; Ji J; Zhang Z; Cheng X; Li Y; Xiao F; Zhu A; Zhong B; Ruan S; Li J; Ren P; Ou Z; Xiao M; Li M; Deng Z; Zhong H; Li F; Wang WJ; Zhang Y; Chen W; Zhu S; Xu X; Jin X; Zhao J; Zhong N; Zhang W; Zhao J; Li J; Xu Y
  • Front Med (Lausanne) 2021[]; 8 (ä): 585358 PMID33659260show ga
  • The emergence of the novel human coronavirus, SARS-CoV-2, causes a global COVID-19 (coronavirus disease 2019) pandemic. Here, we have characterized and compared viral populations of SARS-CoV-2 among COVID-19 patients within and across households. Our work showed an active viral replication activity in the human respiratory tract and the co-existence of genetically distinct viruses within the same host. The inter-host comparison among viral populations further revealed a narrow transmission bottleneck between patients from the same households, suggesting a dominated role of stochastic dynamics in both inter-host and intra-host evolutions.
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