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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Front+Med+(Lausanne) 2021 ; 8 (ä): 585358 Nephropedia Template TP
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Population Bottlenecks and Intra-host Evolution During Human-to-Human Transmission of SARS-CoV-2 #MMPMID33659260
Wang D; Wang Y; Sun W; Zhang L; Ji J; Zhang Z; Cheng X; Li Y; Xiao F; Zhu A; Zhong B; Ruan S; Li J; Ren P; Ou Z; Xiao M; Li M; Deng Z; Zhong H; Li F; Wang WJ; Zhang Y; Chen W; Zhu S; Xu X; Jin X; Zhao J; Zhong N; Zhang W; Zhao J; Li J; Xu Y
Front Med (Lausanne) 2021[]; 8 (ä): 585358 PMID33659260show ga
The emergence of the novel human coronavirus, SARS-CoV-2, causes a global COVID-19 (coronavirus disease 2019) pandemic. Here, we have characterized and compared viral populations of SARS-CoV-2 among COVID-19 patients within and across households. Our work showed an active viral replication activity in the human respiratory tract and the co-existence of genetically distinct viruses within the same host. The inter-host comparison among viral populations further revealed a narrow transmission bottleneck between patients from the same households, suggesting a dominated role of stochastic dynamics in both inter-host and intra-host evolutions.