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10.3389/fgene.2021.571707

http://scihub22266oqcxt.onion/10.3389/fgene.2021.571707
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33659022!7917236!33659022
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suck abstract from ncbi


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pmid33659022      Front+Genet 2021 ; 12 (ä): 571707
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  • SARS CoV-2 Spike Protein in silico Interaction With ACE2 Receptors From Wild and Domestic Species #MMPMID33659022
  • Rendon-Marin S; Martinez-Gutierrez M; Whittaker GR; Jaimes JA; Ruiz-Saenz J
  • Front Genet 2021[]; 12 (ä): 571707 PMID33659022show ga
  • The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been declared a pandemic by the World Health Organization (WHO), and since its first report, it has become a major public health concern. SARS-CoV-2 is closely related to SARS-CoV and SARS-related bat coronaviruses, and it has been described to use angiotensin-converting enzyme 2 (ACE2) as a receptor. Natural SARS-CoV-2 infection in domestic and wildlife animals, measured by RT-qPCR, has been confirmed in different countries, especially from the Felidae family. In silico analysis of the interaction between the SARS-CoV-2 spike protein and the cellular receptor ACE2 in various animal species has suggested that wild felids and domestic cats could be susceptible to SARS-CoV-2 based on this interaction. Here, we performed a protein-protein molecular docking analysis of SARS-CoV-2 spike protein with the ACE2 receptor from different animals to elucidate the potential of those species as intermediate hosts or susceptible animals for SARS-CoV-2 infection. Compared to human ACE2, we found that ACE2 receptors from domestic cats and tigers could efficiently interact with RBD of SARS CoV-2 Spike protein. However, dog, ferret, and hamster ACE2 receptor interaction with SARS-CoV-2 S protein RBD was not predicted as favorable, demonstrating a potential differentiated susceptibility in the evaluated species.
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