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10.1126/scitranslmed.abe5449 http://scihub22266oqcxt.onion/10.1126/scitranslmed.abe5449 33658355!ä!33658355 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Transl+Med 2021 ; 13 (583): ä Nephropedia Template TP {{tp|p=33658355|t=2021. Broad neutralization of H1 and H3 viruses by adjuvanted influenza HA stem vaccines in nonhuman primates |pdf=|usr=}}{{33658355}} gab.com Text Broad neutralization of H1 and H3 viruses by adjuvanted influenza HA stem vaccines in nonhuman primates JO: Sci Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=33658355 #FOAvip Seasonal influenza vaccines confer protection against specific viral strains but have restricted breadth that limits their protective efficacy. The H1 and H3 subtypes of influenza A virus cause most of the seasonal epidemics observed in humans and are the major drivers of influenza A virus-associated mortality. The consequences of pandemic spread of COVID-19 underscore the public health importance of prospective vaccine development. Here, we show that headless hemagglutinin (HA) stabilized-stem immunogens presented on ferritin nanoparticles elicit broadly neutralizing antibody (bnAb) responses to diverse H1 and H3 viruses in nonhuman primates (NHPs) when delivered with a squalene-based oil-in-water emulsion adjuvant, AF03. The neutralization potency and breadth of antibodies isolated from NHPs were comparable to human bnAbs and extended to mismatched heterosubtypic influenza viruses. Although NHPs lack the immunoglobulin germline VH1-69 residues associated with the most prevalent human stem-directed bnAbs, other gene families compensated to generate bnAbs. Isolation and structural analyses of vaccine-induced bnAbs revealed extensive interaction with the fusion peptide on the HA stem, which is essential for viral entry. Antibodies elicited by these headless HA stabilized-stem vaccines neutralized diverse H1 and H3 influenza viruses and shared a mode of recognition analogous to human bnAbs, suggesting that these vaccines have the potential to confer broadly protective immunity against diverse viruses responsible for seasonal and pandemic influenza infections in humans. Twit Text FOAVip Broad neutralization of H1 and H3 viruses by adjuvanted influenza HA stem vaccines in nonhuman primates ????Sci Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=33658355 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33658355 #FOAvip English Wikipedia <ref>{{Cite pmid|33658355}}</ref> Broad neutralization of H1 and H3 viruses by adjuvanted influenza HA stem vaccines in nonhuman primates #MMPMID33658355 Darricarrere N; Qiu Y; Kanekiyo M; Creanga A; Gillespie RA; Moin SM; Saleh J; Sancho J; Chou TH; Zhou Y; Zhang R; Dai S; Moody A; Saunders KO; Crank MC; Mascola JR; Graham BS; Wei CJ; Nabel GJ Sci Transl Med 2021[Mar]; 13 (583): ä PMID33658355show ga Seasonal influenza vaccines confer protection against specific viral strains but have restricted breadth that limits their protective efficacy. The H1 and H3 subtypes of influenza A virus cause most of the seasonal epidemics observed in humans and are the major drivers of influenza A virus-associated mortality. The consequences of pandemic spread of COVID-19 underscore the public health importance of prospective vaccine development. Here, we show that headless hemagglutinin (HA) stabilized-stem immunogens presented on ferritin nanoparticles elicit broadly neutralizing antibody (bnAb) responses to diverse H1 and H3 viruses in nonhuman primates (NHPs) when delivered with a squalene-based oil-in-water emulsion adjuvant, AF03. The neutralization potency and breadth of antibodies isolated from NHPs were comparable to human bnAbs and extended to mismatched heterosubtypic influenza viruses. Although NHPs lack the immunoglobulin germline VH1-69 residues associated with the most prevalent human stem-directed bnAbs, other gene families compensated to generate bnAbs. Isolation and structural analyses of vaccine-induced bnAbs revealed extensive interaction with the fusion peptide on the HA stem, which is essential for viral entry. Antibodies elicited by these headless HA stabilized-stem vaccines neutralized diverse H1 and H3 influenza viruses and shared a mode of recognition analogous to human bnAbs, suggesting that these vaccines have the potential to confer broadly protective immunity against diverse viruses responsible for seasonal and pandemic influenza infections in humans. |Animals[MESH] |Antibodies, Viral/biosynthesis/chemistry[MESH] |Antigen-Antibody Complex/chemistry[MESH] |Broadly Neutralizing Antibodies/biosynthesis/chemistry[MESH] |COVID-19[MESH] |Ferritins/chemistry/immunology[MESH] |Hemagglutinin Glycoproteins, Influenza Virus/chemistry/genetics/*immunology[MESH] |Humans[MESH] |Influenza Vaccines/administration & dosage/chemistry/*immunology[MESH] |Influenza, Human/immunology/virology[MESH] |Macaca fascicularis[MESH] |Models, Molecular[MESH] |Nanoparticles/chemistry[MESH] |Pandemics[MESH] |Primates/*immunology/virology[MESH] |Protein Structure, Quaternary[MESH] |SARS-CoV-2[MESH]Broad neutralization of H1 and H3 viruses by adjuvanted influenza HA s(epmc).pdf DeepDyve Pubget Overpricing