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10.1186/s12931-021-01666-3 http://scihub22266oqcxt.onion/10.1186/s12931-021-01666-3 33658032!7928197!33658032     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Respir+Res 2021 ; 22 (1): 76 Nephropedia Template TP {{tp|p=33658032|t=2021. Circulating Vitamin D levels status and clinical prognostic indices in COVID-19 patients |pdf=|usr=}}{{33658032}} gab.com Text Circulating Vitamin D levels status and clinical prognostic indices in COVID-19 patients JO: Respir Res http://www.kidney.de/pget.php?&tw=1&pmid=33658032 #FOAvip BACKGROUND: Several immune mechanisms activate in COVID-19 pathogenesis. Usually, coronavirus infection is characterized by dysregulated host immune responses, interleukine-6 increase, hyper-activation of cytotoxic CD8 T lymphocytes. Interestingly, Vitamin D deficiency has been often associated with altered immune responses and infections. In the present study, we evaluated Vitamin D plasma levels in patients affected with different lung involvement during COVID-19 infection. METHODS: Lymphocyte phenotypes were assessed by flow cytometry. Thoracic CT scan involvement was obtained by an image analysis program. RESULTS: Vitamin D levels were deficient in (80%) of patients, insufficient in (6.5%) and normal in (13.5%). Patients with very low Vitamin D plasma levels had more elevated D-Dimer values, a more elevated B lymphocyte cell count, a reduction of CD8 + T lymphocytes with a low CD4/CD8 ratio, more compromised clinical findings (measured by LIPI and SOFA scores) and thoracic CT scan involvement. CONCLUSIONS: Vitamin D deficiency is associated with compromised inflammatory responses and higher pulmonary involvement in COVID-19 affected patients. Vitamin D assessment, during COVID-19 infection, could be a useful analysis for possible therapeutic interventions. TRIAL REGISTRATION: 'retrospectively registered'. Twit Text FOAVip Circulating Vitamin D levels status and clinical prognostic indices in COVID-19 patients ????Respir Res http://www.kidney.de/pget.php?&tw=1&pmid=33658032 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33658032 #FOAvip English Wikipedia <ref>{{Cite pmid|33658032}}</ref> Circulating Vitamin D levels status and clinical prognostic indices in COVID-19 patients #MMPMID33658032 Ricci A; Pagliuca A; D'Ascanio M; Innammorato M; De Vitis C; Mancini R; Giovagnoli S; Facchiano F; Sposato B; Anibaldi P; Marcolongo A; De Dominicis C; Laghi A; Muscogiuri E; Sciacchitano S Respir Res 2021[Mar]; 22 (1): 76 PMID33658032show ga BACKGROUND: Several immune mechanisms activate in COVID-19 pathogenesis. Usually, coronavirus infection is characterized by dysregulated host immune responses, interleukine-6 increase, hyper-activation of cytotoxic CD8 T lymphocytes. Interestingly, Vitamin D deficiency has been often associated with altered immune responses and infections. In the present study, we evaluated Vitamin D plasma levels in patients affected with different lung involvement during COVID-19 infection. METHODS: Lymphocyte phenotypes were assessed by flow cytometry. Thoracic CT scan involvement was obtained by an image analysis program. RESULTS: Vitamin D levels were deficient in (80%) of patients, insufficient in (6.5%) and normal in (13.5%). Patients with very low Vitamin D plasma levels had more elevated D-Dimer values, a more elevated B lymphocyte cell count, a reduction of CD8 + T lymphocytes with a low CD4/CD8 ratio, more compromised clinical findings (measured by LIPI and SOFA scores) and thoracic CT scan involvement. CONCLUSIONS: Vitamin D deficiency is associated with compromised inflammatory responses and higher pulmonary involvement in COVID-19 affected patients. Vitamin D assessment, during COVID-19 infection, could be a useful analysis for possible therapeutic interventions. TRIAL REGISTRATION: 'retrospectively registered'. |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |CD8-Positive T-Lymphocytes/metabolism[MESH] |COVID-19/*blood/diagnostic imaging/*epidemiology[MESH] |Female[MESH] |Humans[MESH] |Italy/epidemiology[MESH] |Lung/diagnostic imaging[MESH] |Male[MESH] |Middle Aged[MESH] |Prognosis[MESH] |Vitamin D Deficiency/*blood/diagnostic imaging/*epidemiology[MESH]Circulating Vitamin D levels status and clinical prognostic indices in(epmc).pdf DeepDyve Pubget Overpricing