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10.1111/eci.13531 http://scihub22266oqcxt.onion/10.1111/eci.13531 33657664!7995001!33657664     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33657664&cmd=llinks): Failed to open stream: HTTP request failed! 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Mid-regional pro-atrial natriuretic peptide independently predicts short-term mortality in COVID-19 |pdf=|usr=}}{{33657664}} gab.com Text Mid-regional pro-atrial natriuretic peptide independently predicts short-term mortality in COVID-19 JO: Eur J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=33657664 #FOAvip BACKGROUND: Mid-regional pro-atrial natriuretic peptide (MR-proANP) is a strong prognostic marker in several inflammatory, respiratory and cardiovascular conditions, but has not been studied in COVID-19 yet. METHODS: This prospective, observational study of patients with COVID-19 infection was conducted from 6 June to 26 November 2020 in different wards of a tertiary hospital. MR-proANP, N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitive cardiac troponin I levels on admission were collected and tested for their association with disease severity and 28-day mortality. RESULTS: A total of 213 eligible patients with COVID-19 were included in the final analyses of whom 13.2% (n = 28) died within 28 days. Median levels of MR-proANP at admission were significantly higher in nonsurvivors (307 pmol/L IQR, [161 - 532] vs 75 pmol/L [IQR, 43 - 153], P < .001) compared to survivors and increased with disease severity and level of hypoxaemia. The area under the ROC curve for MR-proANP predicting 28-day mortality was 0.832 (95% CI 0.753 - 0.912, P < .001). An optimal cut-off point of 160 pmol/L yielded a sensitivity of 82.1% and a specificity of 76.2%. MR-proANP was a significant predictor of 28-day mortality independent of clinical confounders, comorbidities and established prognostic markers of COVID-19 (HR 2.77, 95% CI 1.21 - 6.37; P = .016), while NT-proBNP failed to independently predict 28-day mortality and had a numerically lower AUC compared to MR-proANP. CONCLUSION: Higher levels of MR-proANP at admission are associated with disease severity of COVID-19 and act as a powerful and independent prognostic marker of 28-day mortality. Twit Text FOAVip Mid-regional pro-atrial natriuretic peptide independently predicts short-term mortality in COVID-19 ????Eur J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=33657664 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33657664 #FOAvip English Wikipedia <ref>{{Cite pmid|33657664}}</ref> Mid-regional pro-atrial natriuretic peptide independently predicts short-term mortality in COVID-19 #MMPMID33657664 Kaufmann CC; Ahmed A; Kassem M; Freynhofer MK; Jager B; Aicher G; Equiluz-Bruck S; Spiel AO; Funk GC; Gschwantler M; Fasching P; Wojta J; Huber K Eur J Clin Invest 2021[May]; 51 (5): e13531 PMID33657664show ga BACKGROUND: Mid-regional pro-atrial natriuretic peptide (MR-proANP) is a strong prognostic marker in several inflammatory, respiratory and cardiovascular conditions, but has not been studied in COVID-19 yet. METHODS: This prospective, observational study of patients with COVID-19 infection was conducted from 6 June to 26 November 2020 in different wards of a tertiary hospital. MR-proANP, N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitive cardiac troponin I levels on admission were collected and tested for their association with disease severity and 28-day mortality. RESULTS: A total of 213 eligible patients with COVID-19 were included in the final analyses of whom 13.2% (n = 28) died within 28 days. Median levels of MR-proANP at admission were significantly higher in nonsurvivors (307 pmol/L IQR, [161 - 532] vs 75 pmol/L [IQR, 43 - 153], P < .001) compared to survivors and increased with disease severity and level of hypoxaemia. The area under the ROC curve for MR-proANP predicting 28-day mortality was 0.832 (95% CI 0.753 - 0.912, P < .001). An optimal cut-off point of 160 pmol/L yielded a sensitivity of 82.1% and a specificity of 76.2%. MR-proANP was a significant predictor of 28-day mortality independent of clinical confounders, comorbidities and established prognostic markers of COVID-19 (HR 2.77, 95% CI 1.21 - 6.37; P = .016), while NT-proBNP failed to independently predict 28-day mortality and had a numerically lower AUC compared to MR-proANP. CONCLUSION: Higher levels of MR-proANP at admission are associated with disease severity of COVID-19 and act as a powerful and independent prognostic marker of 28-day mortality. |*Mortality[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Atrial Natriuretic Factor/*blood[MESH] |COVID-19/*blood[MESH] |Case-Control Studies[MESH] |Cause of Death[MESH] |Female[MESH] |Hospitalization[MESH] |Humans[MESH] |Hypoxia/blood[MESH] |Male[MESH] |Middle Aged[MESH] |Natriuretic Peptide, Brain/*blood[MESH] |Peptide Fragments/*blood[MESH] |Prospective Studies[MESH] |ROC Curve[MESH] |SARS-CoV-2[MESH] |Severity of Illness Index[MESH]Mid-regional pro-atrial natriuretic peptide independently predicts sho(epmc).pdf DeepDyve Pubget Overpricing