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10.1016/j.mehy.2021.110543 http://scihub22266oqcxt.onion/10.1016/j.mehy.2021.110543 33657459!7890339!33657459     free     free     free       Med+Hypotheses 2021 ; 149 (ä): 110543 Nephropedia Template TP {{tp|p=33657459|t=2021. COVID-19: A methyl-group assault?|pdf=|usr=}}{{33657459}} gab.com Text COVID-19: A methyl-group assault JO: Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=33657459 #FOAvip The socio-economic implications of COVID-19 are devastating. Considerable morbidity is attributed to 'long-COVID' - an increasingly recognized complication of infection. Its diverse symptoms are reminiscent of vitamin B(12) deficiency, a condition in which methylation status is compromised. We suggest why SARS-CoV-2 infection likely leads to increased methyl-group requirements and other disturbances of one-carbon metabolism. We propose these might explain the varied symptoms of long-COVID. Our suggested mechanismmight also apply to similar conditions such as myalgic encephalomyelitis/chronic fatigue syndrome. The hypothesis is evaluable by detailed determination of vitamin B(12)and folate status, including serum formate as well as homocysteine and methylmalonic acid, and correlation with viral and host RNA methylation and symptomatology. If confirmed, methyl-group support should prove beneficial in such individuals. Twit Text FOAVip COVID-19: A methyl-group assault ????Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=33657459 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33657459 #FOAvip English Wikipedia <ref>{{Cite pmid|33657459}}</ref> COVID-19: A methyl-group assault? #MMPMID33657459 McCaddon A; Regland B Med Hypotheses 2021[Apr]; 149 (ä): 110543 PMID33657459show ga The socio-economic implications of COVID-19 are devastating. Considerable morbidity is attributed to 'long-COVID' - an increasingly recognized complication of infection. Its diverse symptoms are reminiscent of vitamin B(12) deficiency, a condition in which methylation status is compromised. We suggest why SARS-CoV-2 infection likely leads to increased methyl-group requirements and other disturbances of one-carbon metabolism. We propose these might explain the varied symptoms of long-COVID. Our suggested mechanismmight also apply to similar conditions such as myalgic encephalomyelitis/chronic fatigue syndrome. The hypothesis is evaluable by detailed determination of vitamin B(12)and folate status, including serum formate as well as homocysteine and methylmalonic acid, and correlation with viral and host RNA methylation and symptomatology. If confirmed, methyl-group support should prove beneficial in such individuals. |Adenosine/analogs & derivatives/chemistry[MESH] |COVID-19/blood/*complications/physiopathology[MESH] |Folic Acid Deficiency[MESH] |Folic Acid/*blood[MESH] |Formates/blood[MESH] |Genome, Viral[MESH] |Glutathione/blood[MESH] |Homocysteine/blood[MESH] |Hospitalization[MESH] |Humans[MESH] |Methylation[MESH] |Methylmalonic Acid/blood[MESH] |Oxidative Stress[MESH] |Post-Acute COVID-19 Syndrome[MESH] |RNA/chemistry[MESH] |Serine/blood[MESH] |Vitamin B 12 Deficiency/*diagnosis[MESH]COVID-19: A methyl-group assault?(epmc).pdf DeepDyve Pubget Overpricing