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10.1371/journal.pone.0247251

http://scihub22266oqcxt.onion/10.1371/journal.pone.0247251
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33657157!7928439!33657157
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suck abstract from ncbi

pmid33657157      PLoS+One 2021 ; 16 (3): e0247251
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  • A propensity score-matched analysis of mortality in solid organ transplant patients with COVID-19 compared to non-solid organ transplant patients #MMPMID33657157
  • Linares L; Cofan F; Diekmann F; Herrera S; Marcos MA; Castel MA; Farrero M; Colmenero J; Ruiz P; Crespo G; Llopis J; Garcia-Vidal C; Soriano A; Moreno A; Bodro M
  • PLoS One 2021[]; 16 (3): e0247251 PMID33657157show ga
  • In the context of COVID-19 pandemic, we aimed to analyze the epidemiology, clinical characteristics, risk factors for mortality and impact of COVID-19 on outcomes of solid organ transplant (SOT) recipients compared to a cohort of non transplant patients, evaluating if transplantation could be considered a risk factor for mortality. From March to May 2020, 261 hospitalized patients with COVID-19 pneumonia were evaluated, including 41 SOT recipients. Of these, thirty-two were kidney recipients, 4 liver, 3 heart and 2 combined kidney-liver transplants. Median time from transplantation to COVID-19 diagnosis was 6 years. Thirteen SOT recipients (32%) required Intensive Care Unit (ICU) admission and 5 patients died (12%). Using a propensity score match analysis, we found no significant differences between SOT recipients and non-transplant patients. Older age (OR 1.142; 95% [CI 1.08-1.197]) higher levels of C-reactive protein (OR 3.068; 95% [CI 1.22-7.71]) and levels of serum creatinine on admission (OR 3.048 95% [CI 1.22-7.57]) were associated with higher mortality. The clinical outcomes of SARS-CoV-2 infection in our cohort of SOT recipients appear to be similar to that observed in the non-transplant population. Older age, higher levels of C-reactive protein and serum creatinine were associated with higher mortality, whereas SOT was not associated with worse outcomes.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Allografts/physiology/virology[MESH]
  • |COVID-19 Testing[MESH]
  • |COVID-19/*complications/epidemiology[MESH]
  • |Cohort Studies[MESH]
  • |Female[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Intensive Care Units[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Organ Transplantation/adverse effects/methods/*mortality[MESH]
  • |Pandemics[MESH]
  • |Propensity Score[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2/pathogenicity[MESH]
  • |Spain/epidemiology[MESH]
  • |Transplant Recipients/statistics & numerical data[MESH]


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