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10.1007/978-3-030-59261-5_9

http://scihub22266oqcxt.onion/10.1007/978-3-030-59261-5_9
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33656717!ä!33656717

suck abstract from ncbi


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pmid33656717      Adv+Exp+Med+Biol 2021 ; 1321 (ä): 109-113
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  • COVID-19 Is an Endothelial Disease: Implications of Nitric Oxide #MMPMID33656717
  • Kidde J; Gorabi AM; Jamialahmadi T; Sahebkar A
  • Adv Exp Med Biol 2021[]; 1321 (ä): 109-113 PMID33656717show ga
  • Endothelial cells are a clinically important infection site for COVID-19, both as a mechanism for disease pathogenesis and as a therapeutic target. People with dysfunctional endothelium, defined by nitric oxide deficiency, appear to have a more severe disease course. As such, nitric oxide has therapeutic potential to mitigate COVID-19 severity. Inhaled nitric oxide appears to improve outcomes, although this strategy neglects systemic endothelium. Meanwhile, early studies have documented that endothelial protective medications, such as the administration of statins and ACE-inhibitors, are associated with less severe disease and reduced mortality. Importantly, these medications augment endothelial sources of nitric oxide, which may explain this effect.
  • |*COVID-19[MESH]
  • |*Nitric Oxide[MESH]
  • |Endothelial Cells[MESH]
  • |Endothelium, Vascular[MESH]
  • |Humans[MESH]


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