Immunodominant antibody germlines in COVID-19 #MMPMID33656515
Andreano E; Rappuoli R
J Exp Med 2021[May]; 218 (5): ä PMID33656515show ga
The neutralizing antibody response to SARS-CoV-2 is dominated by antibodies deriving from germlines IGHV3-53/IGHV3-66, which are also associated with self-reacting antibodies. Could vaccines avoid the expansion of this immunodominant response, decrease the risk of autoimmunity, and still protect against emerging SARS-CoV-2 variants?