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10.1038/s41591-021-01285-x http://scihub22266oqcxt.onion/10.1038/s41591-021-01285-x 33654292!ä!33654292 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Med 2021 ; 27 (4): 622-625 Nephropedia Template TP {{tp|p=33654292|t=2021. SARS-CoV-2 501Y V2 escapes neutralization by South African COVID-19 donor plasma |pdf=|usr=}}{{33654292}} gab.com Text SARS-CoV-2 501Y V2 escapes neutralization by South African COVID-19 donor plasma JO: Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=33654292 #FOAvip SARS-CoV-2 501Y.V2 (B.1.351), a novel lineage of coronavirus causing COVID-19, contains substitutions in two immunodominant domains of the spike protein. Here, we show that pseudovirus expressing 501Y.V2 spike protein completely escapes three classes of therapeutically relevant antibodies. This pseudovirus also exhibits substantial to complete escape from neutralization, but not binding, by convalescent plasma. These data highlight the prospect of reinfection with antigenically distinct variants and foreshadows reduced efficacy of spike-based vaccines. Twit Text FOAVip SARS-CoV-2 501Y V2 escapes neutralization by South African COVID-19 donor plasma ????Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=33654292 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33654292 #FOAvip English Wikipedia <ref>{{Cite pmid|33654292}}</ref> SARS-CoV-2 501Y V2 escapes neutralization by South African COVID-19 donor plasma #MMPMID33654292 Wibmer CK; Ayres F; Hermanus T; Madzivhandila M; Kgagudi P; Oosthuysen B; Lambson BE; de Oliveira T; Vermeulen M; van der Berg K; Rossouw T; Boswell M; Ueckermann V; Meiring S; von Gottberg A; Cohen C; Morris L; Bhiman JN; Moore PL Nat Med 2021[Apr]; 27 (4): 622-625 PMID33654292show ga SARS-CoV-2 501Y.V2 (B.1.351), a novel lineage of coronavirus causing COVID-19, contains substitutions in two immunodominant domains of the spike protein. Here, we show that pseudovirus expressing 501Y.V2 spike protein completely escapes three classes of therapeutically relevant antibodies. This pseudovirus also exhibits substantial to complete escape from neutralization, but not binding, by convalescent plasma. These data highlight the prospect of reinfection with antigenically distinct variants and foreshadows reduced efficacy of spike-based vaccines. |*Immune Evasion[MESH] |*Neutralization Tests[MESH] |Antibodies, Viral/chemistry/immunology[MESH] |Blood Donors[MESH] |COVID-19 Vaccines/immunology[MESH] |COVID-19/*immunology[MESH] |Humans[MESH] |SARS-CoV-2/*immunology[MESH]SARS-CoV-2 501Y V2 escapes neutralization by South African COVID-19 do(epmc).pdf DeepDyve Pubget Overpricing