Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1126/sciimmunol.abf7570 http://scihub22266oqcxt.onion/10.1126/sciimmunol.abf7570 33653907!8128303!33653907     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33653907&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Immunol 2021 ; 6 (57): ä Nephropedia Template TP {{tp|p=33653907|t=2021. Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19 |pdf=|usr=}}{{33653907}} gab.com Text Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19 JO: Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33653907 #FOAvip Pediatric COVID-19 following SARS-CoV-2 infection is associated with fewer hospitalizations and often milder disease than in adults. A subset of children, however, present with Multisystem Inflammatory Syndrome in Children (MIS-C) that can lead to vascular complications and shock, but rarely death. The immune features of MIS-C compared to pediatric COVID-19 or adult disease remain poorly understood. We analyzed peripheral blood immune responses in hospitalized SARS-CoV-2 infected pediatric patients (pediatric COVID-19) and patients with MIS-C. MIS-C patients had patterns of T cell-biased lymphopenia and T cell activation similar to severely ill adults, and all patients with MIS-C had SARS-CoV-2 spike-specific antibodies at admission. A distinct feature of MIS-C patients was robust activation of vascular patrolling CX3CR1+ CD8+ T cells that correlated with the use of vasoactive medication. Finally, whereas pediatric COVID-19 patients with acute respiratory distress syndrome (ARDS) had sustained immune activation, MIS-C patients displayed clinical improvement over time, concomitant with decreasing immune activation. Thus, non-MIS-C versus MIS-C SARS-CoV-2 associated illnesses are characterized by divergent immune signatures that are temporally distinct from one another and implicate CD8+ T cells in the clinical presentation and trajectory of MIS-C. Twit Text FOAVip Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19 ????Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33653907 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33653907 #FOAvip English Wikipedia <ref>{{Cite pmid|33653907}}</ref> Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19 #MMPMID33653907 Vella LA; Giles JR; Baxter AE; Oldridge DA; Diorio C; Kuri-Cervantes L; Alanio C; Pampena MB; Wu JE; Chen Z; Huang YJ; Anderson EM; Gouma S; McNerney KO; Chase J; Burudpakdee C; Lee JH; Apostolidis SA; Huang AC; Mathew D; Kuthuru O; Goodwin EC; Weirick ME; Bolton MJ; Arevalo CP; Ramos A; Jasen CJ; Conrey PE; Sayed S; Giannini HM; D'Andrea K; Meyer NJ; Behrens EM; Bassiri H; Hensley SE; Henrickson SE; Teachey DT; Betts MR; Wherry EJ Sci Immunol 2021[Mar]; 6 (57): ä PMID33653907show ga Pediatric COVID-19 following SARS-CoV-2 infection is associated with fewer hospitalizations and often milder disease than in adults. A subset of children, however, present with Multisystem Inflammatory Syndrome in Children (MIS-C) that can lead to vascular complications and shock, but rarely death. The immune features of MIS-C compared to pediatric COVID-19 or adult disease remain poorly understood. We analyzed peripheral blood immune responses in hospitalized SARS-CoV-2 infected pediatric patients (pediatric COVID-19) and patients with MIS-C. MIS-C patients had patterns of T cell-biased lymphopenia and T cell activation similar to severely ill adults, and all patients with MIS-C had SARS-CoV-2 spike-specific antibodies at admission. A distinct feature of MIS-C patients was robust activation of vascular patrolling CX3CR1+ CD8+ T cells that correlated with the use of vasoactive medication. Finally, whereas pediatric COVID-19 patients with acute respiratory distress syndrome (ARDS) had sustained immune activation, MIS-C patients displayed clinical improvement over time, concomitant with decreasing immune activation. Thus, non-MIS-C versus MIS-C SARS-CoV-2 associated illnesses are characterized by divergent immune signatures that are temporally distinct from one another and implicate CD8+ T cells in the clinical presentation and trajectory of MIS-C. |*Lymphocyte Activation[MESH] |Adolescent[MESH] |Adult[MESH] |Aging/immunology[MESH] |COVID-19/*immunology[MESH] |Child[MESH] |Child, Preschool[MESH] |Female[MESH] |Flow Cytometry[MESH] |Humans[MESH] |Leukopenia/immunology[MESH] |Male[MESH] |Systemic Inflammatory Response Syndrome/*immunology[MESH] |T-Lymphocytes/*immunology[MESH]Deep immune profiling of MIS-C demonstrates marked but transient immun(epmc).pdf DeepDyve Pubget Overpricing